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Biomarker Menu

Bioclinica Lab offers more than 70 biochemical assays (efficacy biomarkers, predictive biomarkers, and safety biomarkers) to help our customers evaluate the therapeutic potential of their investigational compounds in clinical trials and orient their drug development programs. Our laboratory is equipped with robotics and Multiplex capabilities to offer our clients the latest methods for analyzing multiple biomarkers in parallel.

All biomarker assays have been validated in-house according to current international guidelines. We can perform an assay validation of customer-selected biomarkers or adapt assays to special biological matrices like BALF, Synovial or Cerebrospinal fluids.

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Matrices Title Therapeutic Areas
Serum 1,25OH VitD // 1,25-Dihydroxyvitamin D Musculoskeletal
Serum 25OH VitD // 25-Hydroxyvitamin D Musculoskeletal
Serum Adiponectin // Acrp30 Metabolic Disease, Cardiovascular
Serum Anti-CCP // Antibody to Cyclic Citrullinated Peptide Inflammatory Disease
Cerebrospinal Fluid Aβ 1-40 // Beta Amyloid 1-40 Neuroscience
Cerebrospinal Fluid Aβ 1-42 // Beta Amyloid 1-42 Neuroscience
Serum BAFF // B Cell Activating Factor Inflammatory Disease, New
Serum BAP // Bone Alkaline Phosphatase Musculoskeletal
Serum Bone TRAP // Bone Tartrate Resistant Acid Phosphatase Musculoskeletal
Serum C1, 2C // Type I and Type II Collagen 3/4C Short Musculoskeletal
Serum C2C // C-Terminal of the 3/4 Piece of Type II Collagen Musculoskeletal
Serum Calcitonin Musculoskeletal
Serum, Urine Calcium Metabolic Disease, Musculoskeletal
Urine cAMP // Cyclic Adenosine Monophosphate Cardiovascular
Serum CGA // Chromogranin A Oncology
Serum CICP // Procollagen Type I C-Propeptide Musculoskeletal
Plasma, Serum, Urine COL4 // Type IV Collagen Oncology
Serum, Synovial Fluid COMP // Cartilage Oligomeric Matrix Protein Musculoskeletal
Serum CPII (PIICP) // Procollagen Type II C-Propeptide Musculoskeletal
Serum, Urine CREAT // Creatinine Metabolic Disease, Musculoskeletal
Serum, Synovial Fluid CS846 // Chondroitin Sulfate 846 Epitope Musculoskeletal
Serum, Urine CTX-I // C-Terminal Crosslinked Telopeptide of Type I Collagen Musculoskeletal, Oncology
Urine CTX-II // C-Terminal Telopeptide of Type II Collagen Musculoskeletal
Serum CXCL10 // C-X-C motif chemokine 10 Inflammatory Disease
Serum CXCL13 // C-X-C motif chemokine 13 Inflammatory Disease
Serum CXCL8/IL8 // C-X-C motif chemokine 8 / Interleukin 8 Inflammatory Disease
Plasma, Serum DKK-1 // Dickkopf Related Protein-1 Musculoskeletal
Urine DPD // Deoxypiridinoline Crosslinks Musculoskeletal
Urine DPD, Total // Total Deoxypiridinoline Crosslinks Musculoskeletal
Serum Ferritin New, Cardiovascular
Serum Fetuin-A Musculoskeletal
Serum FSH // Follico-Stimulating Hormone Metabolic Disease
Serum HA // Hyaluronic Acid Musculoskeletal
Serum Hepcidin New, Cardiovascular
Serum hs-CRP // High Sensitivity C-Reactive Protein Inflammatory Disease, Cardiovascular
Serum ICAM 1 // Intercellular Adhesion Molecule 1 Inflammatory Disease
Serum ICTP // C-Terminal Telopeptide of Type I Collagen Musculoskeletal, Oncology
Serum IGF-1 // Insulin-Like Growth Factor I or Somatomedin C Metabolic Disease
Serum IGFBP-3 // Insulin-Like Growth Factor Binding Protein 3 Metabolic Disease
Serum IL-18 // Interleukin 18 Inflammatory Disease
Serum IL-1β // Interleukin 1 beta Inflammatory Disease
Serum, Synovial Fluid IL-6 // Interleukin 6 Inflammatory Disease
Serum Iron New, Cardiovascular
Serum Lipoprotein A Lp(a) New, Cardiovascular
Serum MMP-1 // Pro-Matrix Metalloproteinase 1 Inflammatory Disease
Synovial Fluid MMP-13 // Pro-Matrix Metalloproteinase 13 Musculoskeletal, Oncology
Serum, Synovial Fluid MMP-3 // Active and Pro-Matrix Metalloproteinase 3 Inflammatory Disease
Synovial Fluid MMP-8 // Total Matrix Metalloproteinase 8 Musculoskeletal, Oncology
Serum MMP-9 // Active and Pro-Matrix Metalloproteinase 9 Inflammatory Disease, Oncology, Cardiovascular
Plasma MPO // Myeloperoxidase Inflammatory Disease, Cardiovascular
Serum MRP 8/14 // Myeloid Related Protein 8 and Myeloid Related Protein 14 (S100A8/S100A9, Calprotectin) Inflammatory Disease, New
Cerebrospinal Fluid Neurogranin Neuroscience, New
Serum, Urine NTX-I // N-Terminal Crosslinked Telopeptide of Type I Collagen Musculoskeletal
Serum OC // Osteocalcin Musculoskeletal
Serum OPG // Osteoprotegerin Musculoskeletal
Plasma OPN / / Osteopontin Musculoskeletal, Oncology
Synovial Fluid PGE2 // Prostaglandin E2 Inflammatory Disease
Serum, Urine Phosphorus Metabolic Disease, Musculoskeletal
Serum PIIANP // Procollagen Type IIA N-Propeptide Musculoskeletal
Serum PIICP (CPII) // Procollagen Type II C-Propeptide Musculoskeletal
Serum PIIINP // Intact N-Terminal Propeptide Of Type III Collagen Oncology
Serum PINP // Procollagen Type I N-Propeptide Musculoskeletal, Oncology
Serum PSA // Prostate Specific Antigen Oncology
Plasma, Serum PTH, Intact // Intact Parathyroid Hormone Metabolic Disease, Musculoskeletal
Plasma PTH, Whole // Whole Parathyroid Hormone Metabolic Disease, Musculoskeletal
Urine PYD // Pyridinium Crosslinks Musculoskeletal
Serum Serum Amyloid A (SAA) New, Cardiovascular
Serum sgp 130 // Soluble Glycoprotein 130 Inflammatory Disease
Serum SOST // Sclerostin Musculoskeletal
Serum sRANKL (Total) // Total Soluble Receptor Activator of Nuclear Factor Kappa B Ligand Musculoskeletal, Oncology
Serum sRANKL // Free Soluble Receptor Activator of Nuclear Factor Kappa B Ligand Musculoskeletal, Oncology
Serum Survivin Oncology
Cerebrospinal Fluid T-tau // Total Tau Neuroscience
Serum TGF-β1 // Transforming Growth Factor beta 1 Inflammatory Disease
Serum, Synovial Fluid TIMP-1 // Tissue Inhibitor of Metalloproteinase 1 Inflammatory Disease, Oncology
Serum, Synovial Fluid TNF-α // Tumor Necrosis Factor alpha Inflammatory Disease
Serum Total iron-binding capacity (TIBC) New, Cardiovascular
Serum UcOC // Undercarboxylated Osteocalcin Musculoskeletal
Plasma VEGF-A // Vascular Endothelial Growth Factor Inflammatory Disease, Oncology, Cardiovascular
Urine α CTX-I // Alpha C-Terminal Crosslinked Telopeptide of Type I Collagen Musculoskeletal


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Bioclinica is divided into three business segments so that we can provide expert service and multifaceted technologies. Our Medical Imaging and Biomarkers segment includes an Imaging Core Lab, a Cardiovascular Safety division, and a Biomarker Laboratory. Our eHealth segment comprises an eClinical Solutions Division along with Safety and Regulatory Solutions. Under the Global Clinical Research segment, we offer a network of research sites, patient recruitment, and a Post-Approval Research division.

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