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C2C // C-Terminal of the 3/4 Piece of Type II Collagen

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In osteoarthritis, cartilage tissue is progressively degraded with denaturation of type II collagen by collagenases. MMP-1, MMP-8 and MMP-13, collagenases known to cleave type II collagen, are believed to act first on a unique site in the triple helix, producing approximately 3/4 ¾ and ¼ lengths denatured α chain (Billinghurst et al., 1997). The C-terminal specific neo-epitope of ¾ short type II collagen can be measured in serum of osteoarthritis patients.

Bioclinica Lab employs a manual competitive immunoassay designed for the measurement of collagen type II fragments containing the neo-epitope in serum (assay calibrated with the 287 peptide).

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