Please Wait...

Ferritin

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Ferritin is a ubiquitous and specialized protein implicated in the intracellular storage of iron. In mammals, ferritin is composed of 24 subunits forming a hallow globular complex whose cavity can store up to 4500 iron atoms (Finazzi and Arosio, 2014). Ferritin-mediated iron storage involves an oxidation process  ̶  conversion of Fe(II) to Fe(III)  ̶  that protects cells from the generation of toxic reactive oxygen species (Recalcati et al., 2008). The iron stored in the ferritin cavity is readily available for high iron demands. Ferritin is mainly localized in the cytoplasm but trace amounts are found in serum, where it is used as an indicator of body iron stores.

Bioclinica Lab employs a quantitative immunoturbidimetry method for the measurement of Ferritin in human serum.

Finazzi, D., and Arosio, P. (2014). Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Arch. Toxicol. 88, 1787–1802.

Recalcati, S., Invernizzi, P., Arosio, P., and Cairo, G. (2008). New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J. Autoimmun. 30, 84–89.

ADDITIONAL RESOURCES

Biomarker Menu

Download MENU

Molecular Marker Laboratory Services

Download Brochure

Alzheimer's Disease Biomarker Lab Expertise

Download Info Sheet

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

RT @virtue_insight: #VIphv We are delighted to announce our new Gold Sponsor @bioclinica for our 16th Pharmacovigilance 2018 https://t.co/h…
bioclinica (41 minutes ago)
RT @bioclinica: Tackling the costly issue of drug supply waste in clinical trials. Find out how Novo Nordisk & other global pharmas R embra…
bioclinica (41 minutes ago)
Tackling the costly issue of drug supply waste in clinical trials. Find out how Novo Nordisk & other global pharmas… https://t.co/iW7Q9DfVgQ
bioclinica (6 days ago)
Background & key considerations to help #pharma prepare for new FDA blood pressure draft guidance issued in May. Ac… https://t.co/07dJeeD35E
bioclinica (2 weeks ago)
Tackling the costly issue of drug supply waste in clinical trials. Find out how Novo Nordisk & other global pharmas… https://t.co/tSx5tm2rgg
bioclinica (3 weeks ago)
DYK @bioclinica offers full-svc global clinical data mgmt svcs customizable to your study & program needs? Our high… https://t.co/dyXDiCtWd8
bioclinica (3 weeks ago)

Latest Blogs:

Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner
Removing Risk from Clinical Trial Management System (CTMS) Implementations