Please Wait...

Ferritin

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Ferritin is a ubiquitous and specialized protein implicated in the intracellular storage of iron. In mammals, ferritin is composed of 24 subunits forming a hallow globular complex whose cavity can store up to 4500 iron atoms (Finazzi and Arosio, 2014). Ferritin-mediated iron storage involves an oxidation process  ̶  conversion of Fe(II) to Fe(III)  ̶  that protects cells from the generation of toxic reactive oxygen species (Recalcati et al., 2008). The iron stored in the ferritin cavity is readily available for high iron demands. Ferritin is mainly localized in the cytoplasm but trace amounts are found in serum, where it is used as an indicator of body iron stores.

Bioclinica Lab employs a quantitative immunoturbidimetry method for the measurement of Ferritin in human serum.

Finazzi, D., and Arosio, P. (2014). Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Arch. Toxicol. 88, 1787–1802.

Recalcati, S., Invernizzi, P., Arosio, P., and Cairo, G. (2008). New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J. Autoimmun. 30, 84–89.

ADDITIONAL RESOURCES

Biomarker Menu

Download MENU

Molecular Marker Laboratory Services

Download Brochure

Alzheimer's Disease Biomarker Lab Expertise

Download Info Sheet

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

On the hunt for agile IRT? Ask these 5 Qs to see if it's the real thing. DISCLOSURE: We happen to have such an offe… https://t.co/S6507WxBC8
bioclinica (6 hours ago)
Be among the 1st to hear findings presented in 6 scientific posters in which experts @bioclinica in #Alzheimers… https://t.co/4mBEtFiX0a
bioclinica (2 days ago)
Still using manual methods for trial budget management and forecasting ? A Bioclinica whitepaper shows how purpose-… https://t.co/WlrHLk9B0z
bioclinica (3 days ago)
Swing by @Bioclinica to discuss global site network partnering opportunities during @MySCRS Asia-Pac Site Solutions… https://t.co/m8GHxSmPMY
bioclinica (4 days ago)
Hello from Clinical Operations in Oncology Trials East Coast where Bioclinica is exhibiting & presenting a case stu… https://t.co/oTKJAVddH4
bioclinica (2 weeks ago)
Challenge overcome! Course-correct a clinical trial & collect 400 time points from 40 sites across the US & EU -- a… https://t.co/n3TLrjW3xi
bioclinica (2 weeks ago)

Latest Blogs:

Latin America: Benefit from the Right Partner
Removing Risk from Clinical Trial Management System (CTMS) Implementations
Collaboration Between Clinical Operations and the Logistics and Supply Chain Teams is Key to Trial Success
The Value of Protocol Review
CTMS and RBM: Hot Topics at OCT Nordics in Copenhagen