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FSH // Follico-Stimulating Hormone

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Follicle-Stimulating Hormone is one of the four glycoprotein hormones. Proteins of this family share a common α subunit and have a specific β subunit. They present structural features of the superfamily of cysteine knot protein (this superfamily contain the TGFβ family, bone morphogenetic proteins, …) (Fan and Hendrickson, 2005; Grossmann et al., 1997; Vitt et al., 2001). FSH is secreted by the pituitary gland and binds its receptor expressed on granulosa cells from ovarian follicles and Sertoli cells of the testis, where activation induce cytodifferentiation, estrogen production and induction of LH receptor. FSH, in association with LH is a central hormone in the regulation of reproduction (Ryan et al., 1988). Injections of recombinant (and urinary) FSH are used in reproductive medicine for ovarian stimulation (van Wely et al., 2011).

Bioclinica Lab employs an automated chemiluminescent assay designed for the measurement of FSH in serum.

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