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Hepcidin

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Hepcidin is a hormone mainly produced by hepatocytes as a precursor pro-peptide which undergoes proteolytic processing to yield its bioactive form of 25 amino-acids. Hepcidin is a key iron regulatory hormone; it inhibits iron entry into the plasma compartment by promoting the degradation of ferroportin, whose fundamental role is to release iron from tissues into the bloodstream (Nemeth et al., 2004a). Hepcidin accumulates after iron intake and under inflammatory conditions resulting in a decreased iron absorption. Conversely, Hepcidin levels drop in iron deficiency. Indeed, Hepcidin synthesis is transcriptionally regulated by the pro-inflammatory cytokine IL-6 and by iron itself resulting in a feedback regulation (Ganz and Nemeth, 2012; Nemeth et al., 2004b).

Bioclinica Lab employs a manual competitive immunoassay for the measurement of the bioactive form of Hepcidin (Hepcidin-25) in human serum.

Ganz, T., and Nemeth, E. (2012). Hepcidin and iron homeostasis. Biochim. Biophys. Acta 1823, 1434–1443.

Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., Ganz, T., and Kaplan, J. (2004a). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090–2093.

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B.K., and Ganz, T. (2004b). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113, 1271–1276.

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