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Neurogranin

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Neurogranin is a post-synaptic protein regulating synaptic plasticity, learning and memory consolidation. Neurogranin is thought to be involved in activity-dependent synaptic plasticity and long-term potentiation through the modulation of calcium-mediated signaling pathways. Because of its abundant and preferential neuronal expression, Neurogranin has been identified as a potential marker of neurodegeneration in large-scale gene arrays,  along with other candidate markers such as VILIP-1 (Laterza et al., 2006). Several studies have shown that CSF Neurogranin levels are increased in AD, even at the early clinical stages, and could predict cognitive deterioration (Janelidze et al., 2015; Portelius et al., 2015; Sun et al., 2016; Thorsell et al., 2010).

Bioclinica Lab employs a manual sandwich immunoassay designed for the measurement of Neurogranin in human cerebrospinal fluid.

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