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OPN / / Osteopontin

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Identified in bone calcified matrix, Osteopontin (OPN) is also called Bone Sialoprotein I and belongs to the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family of protein (Franzen and Heinegard, 1985). OPN contain an RGD motif which allow interaction with integrins and cell surface receptors (Oldberg et al., 1986). OPN interacts with various other partners, can be cleaved by thrombin and in some conditions also by MMP-3 and MMP-7. The resulting fragments have then specific properties which result in modulation of cell migration and adhesion (Bellahcène et al., 2008). Due to its proprieties, OPN is implicated in tumor progression but also in skeletal disorders (Ramchandani and Weber, 2015; Rittling and Chambers, 2004).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of OPN in plasma.

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