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PIIINP // Intact N-Terminal Propeptide Of Type III Collagen

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Type III collagen is present in many tissues, such as skin, vascular vessels, ligaments, skeletal muscles, synovial membrane and connective tissues. Type III collagen is an homotrimer of α1 chains encoded by a single gene (Wu et al., 2010). Collagen type III is synthetized as a large procollagen which is subjected to cleavage of its N-terminal peptide and this N-terminal propeptide of collagen type III (PIINP) is released in the blood circulation in direct proportion to newly formed type III collagen. Serum levels of PIIINP are elevated in remodeling tissues and in some diseases with fibrosis (Chalikias and Tziakas, 2015; Cohen, 2012).

Bioclinica Lab employs a manual competitive radioimmunoassay for the measurement of intact PIIINP in serum.

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