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Osteoporosis

Sarcopenia and Aging: ASBMR Annual Meeting Hot Topic

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  • 10 Jan
Late last year I attended the annual meeting of the American Society of Bone & Mineral Research (ASBMR) in Toronto. One of the hot topics was sarcopenia, a term which describes the process associated with muscle loss, something that occurs as we get older. The term is derived from greek roots, sarx (flesh) and penia (loss). A lot of research has taken place in osteoporosis and its prevention but sarcopenia has considerable clinical significance. Age-related reduction in muscle mass, function and strength leads to the reduced ability to undertake the physical activities of daily living together with an increased risk of fall and related injury. Loss of muscle mass is therefore associated with risk of fracture.
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Are Placebo-Controlled Trials in Osteoporosis Ethical?

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  • 13 Oct
The New England Journal of Medicine has entered the debate around whether it is ethical to have placebo-controlled trials in osteoporosis. For those of us involved in clinical research in osteoporosis, this is a fascinating debate and reflects the challenge between the regulatory requirements and current ethical understanding, which are always intertwined. Placebo in this arena always consists of Vitamin D and Calcium supplementation, which have some bone sparing effects. However, there is a good range of therapies on the market with proven efficacy.
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FRAX iPhone app screen shot – can be used in clinical trials

FRAX iPhone app Tool to Access Fracture Risk in Clinical Trials

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  • 19 May
The iPhone continues to make inroads into all aspects of our lives, and medical imaging and clinical trials have not escaped. Doctot (Doc tools of the trade), an Irish company run by medical and software professionals, recently launched an iPhone app (priced at $5.99 in the US), which makes the WHO Fracture Risk Assessment Tool (FRAX) readily accessible to doctors.
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