At BioClinica, cardiology diagnosis imaging software and treatment are continually updated to reflect the latest developments in centralized quantitative image analysis for cardiology clinical trials. BioClinica provides quantitative analysis in all significant bioimaging modalities including:
Computed Tomography Angiography (CTA) - an emerging technique for visualization of arteries. Using 3-D reconstruction of the vessel, quantitative analysis is performed on the aorta, iliac and carotid arteries. Output from the analysis includes minimal lumen diameter, percent diameter stenosis and lesion length.
Echocardiography Imaging – the gold standard analysis using all modes of Echo for evaluation of left ventricular ejection fraction (LVEF) by LV volumes, left ventricular mass, LV diastolic function, cardiac valve analysis and CHF parameters.
Intima-Media Thickness Measurement Software (IMT) - used with sophisticated analysis packages for atherosclerotic plaques. We recommend carotid images be acquired with ultrasound using the Meijer Arc, a device with predefined angles specially developed by one of our scientists. This ensures image acquisition reproducibility to longitudinal assessments during cardiology clinical trials, and has proven to be extremely useful in multi-center studies.
Intravascular Ultrasound Probe (IVUS) - a catheter-based ultrasound probe that provides tomographic images of both the arterial wall and the lumen of a coronary or vascular vessel segment. BioClinica employs state-of-the-art software specifically designed for 3-D analysis of the vessel, lumen and stent contours (if applicable).
Cardiac MRI - dedicated Medis MRI software that enables the evaluation of cardiac function. Global and regional left ventricular functional parameters such as ejection fraction, left ventricular mass, wall motion and thickening are examples of analysis results. In addition, results on perfusion, infarct size and myocardial viability can be obtained from time-intensity or delayed enhancement cardiology trials.
Magnetic Resonance Angiography Analysis (MRA) - has provided quantitative analysis to assess the effects of lipid lowering drugs on the regression or progression of arteriosclerosis, the efficacy of interventional techniques and the evaluation of MRA contrast media. BioClinica provides analysis involving automatic contour detection in 3-D reconstructions of the vessel of interest.
Quantitative Cardiovascular Angiography (QCA) - analysis involving the assessment of progression and regression of stenosis in drug trials and device studies. QCA is primarily applied in trials investigating new or stent designs in the treatment of coronary artery disease. Software developed by Medis for is used QCA and QVA analysis.
Quantitative Vascular Angiography (QVA) - employed validated software with audit trails is used for quantitative vascular analysis of DICOM and plain film images, subtracted and non-subtracted.
Single Photon Emission Computed Tomography (SPECT) - nuclear medicine software for the quantitative analysis of SPECT images is used. The software evaluates coronary artery disease and assesses the extent and severity of myocardial perfusion abnormalities. Additional analyses can also be performed to determine global and regional function of the ventricle in addition to regional myocardial perfusion.
We apply our therapeutic expertise in cardiology clinical trials to a variety of services, including:
- Medical imaging consulting services
- Image management services
- Site standardization and technical support
- Quantitative image analysis services
- Bio/ImageBase® services