Clinical Trial Abstracts and Posters

Abstracts and Proceedings

2014

Yan Z, Zhang S, Tan C, Zhou Y, Belaroussi B, Yu HJ, Miller C, Metaxas D.  Automatic Liver Segmentation and Hepatic Fat Fraction Assessment in MRI. ICPR, 2014.

Basselerie H, Bracoud L, Schneble HM, Gouttard S, Guignot I, Istace A, Roche F, Schaerer J, Pueyo M, Pachai C, Vellas B, Bonneville F. Microhemorrhage Findings on Baseline Rosas MRI Data. AAIC, 2014.

Istace A, Bracoud L, Berman RM, Luo F, Roche F, Salloway S, van Dyck C, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Ferris S, Grill JD, Gouttard S, Schaerer J, Hayes W, Kaplita S, Belaroussi B, Yu HJ, Cedarbaum JM, Feldman HH, Pachai C, Coric V. Volumetric MRI Results in a Prodromal AD Population. AAIC, 2014.

Yu HJ, Tan C, Yan Z, Belaroussi B, Zhang Y, Metaxas D, Carrino JA, Miller, CG. Tissue Quantification Thigh MRI in Osteoarthritis. IWOAI, 2014.

F. Roche, J. Schaerer, S. Gouttard, A. Istace, B. Belaroussi, HJ. Yu, L. Bracoud, C. Pachai , C. DeCarli and the Alzheimer's Disease Neuroimaging Initiative. Accuracy of BMAS Hippocampus Segmentation Using the Harmonized Hippocampal Protocol. AAIC, 2014.

Yu HJ, Zhang Y, Morges S, Dawson E, Galante N, Belaroussi B, Hoover KB, Miller CG. A Semi-automated Software for Minimal Joint Space Width Detection in Hip Radiographs. IWOAI, 2014.

Kuo P, Heertum RV, Nguyen B, Bateman D, Symanowski J, Naumann R.  A pilot study assessing interreader variability in the evaluation of folate receptor status of ovarian cancer patients using 99mTc-etarfolatide. J Nucl Med. 2014; 55 (Supplement 1):1435

Yu HJ, Zhang Y, Morges S, Dawson E, Galante N, Belaroussi B, Hoover KB, Miller CG. Reproducibility of a Semi-automatic Knee Joint Analysis Tool. IWOAI, 2014.

Tan C, Yan Z, Zhang S, Belaroussi B, Yu HJ, Miller C, Metaxas D.  A Robust and Automatic Framework for Assessment of the Muscle/Fat Fraction in Thigh. ICPR, 2014.

2013

L. Bracoud, K. Marek, J. Cedarbaum, J. Schaerer, S. Mendick, R. Berman, F. Roche, F. Luo, W. Hayes, S. Kaplita, J. Seibyl, C. Pachai, V. Coric and the Alzheimer's Disease Neuroimaging Initiative (2013). Predictive Value of Baseline Hippocampal Volumes and Brain Amyloid Burden on Atrophy Rates for Predementia Alzheimer’s Disease Subjects with Data from Study Cn156-018 and Adni-1.  6th Conference Clinical Trials on Alzheimer’s Disease Abstracts.  November 14–16, 2013 San Diego, CA — USA.

Bracoud, L., S. Gouttard, J. Schaerer, M. Pueyo, F. Bonneville, F. Roche, A. Istace, H.J. Yu, C. Pachai and B. Vellas (2013). Comparison of automated segmentation of intracranial volume between 3D-T1 and 3D-T2 sequences. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P98.

Schaerer, J., B. Singh, F. Roche, B. Belaroussi, E. Fletcher, L. Bracoud, C. Pachai and C. DeCarli (2013). Comparison of manual and automated multi-atlas hippocampal volume measurements in the University of California, Davis, Alzheimer's Disease Center cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P97-P98.

Miller C.G., Yu H.J., Horvath B., Libber J., Krueger D., Binkley N. (2013) Using Body Composition Phantoms to Validate Performance of Dual Energy X-Ray Absorptiometry (DXA) Instrument. J Bone Miner Res 28 (Suppl 1).

Roche, F., B. Singh, J. Schaerer, B. Belaroussi, S. Gouttard, A. Istace, H. J. Yu, E. Fletcher, L. Bracoud, C. Pachai and C. DeCarli (2013). Reproducibility of intracranial and hippocampal volume quantification at 1.5T and 3T MRI: Application to ADNI I. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P271.

L. Bracoud, R. Berman, F. Roche, V. Coric, S. Gouttard, F. Luo, J. Schaerer, W. Hayes, A. Istace, S. Kaplita, B. Belaroussi, H.J. Yu, C. Pachai, J.

Margolin, R., N. Ketter, S. Guthrie, D. Deegan, L. Baher, R. Tschopp, K. Marek, J. Seibyl, G. Novak, J. Streffer, C. Pachai, B. Wyman, K. Booth, E. Yuen, D. Gennevois and E. Liu (2013). Biomarker strategy for enrichment and monitoring of biological effect in ACCTION, a phase II study of ACC-001 (vanutide cridificar) for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P289-P290.

A. Istace, V. Coric, F. Roche, S. Kaplita, J. Schaerer, F. Luo, S. Gouttard, J. Cedarbaum, L. Bracoud, W. Hayes, B. Belaroussi, H.J. Yu, C. Pachai, R. Berman (2013).  Comparison of Boundary Shift Integral and Tensor Based Morphometry to Assess Volume Changes on Whole Brain and Lateral Ventricles – Application To Study Cn156-018. 6th Conference Clinical Trials on Alzheimer’s Disease Abstracts November 14–16, 2013 San Diego, CA — USA.

Gouttard, S., J. Schaerer, H.J. Yu, A. Istace, F. Roche, C. Pachai and L. Bracoud (2013). Impact of parallel imaging on volumetric brain MRI measurements in ADNI-GO and ADNI-2. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P100-P101.

J. Schaerer, F. Luo, S. Gouttard, J. Cedarbaum, L. Bracoud, V. Coric, F. Roche, S. Kaplita, A. Istace, W. Hayes, H.J. Yu, C. Pachai, R. Berman (2013).  Comparison of Intracranial Volume Quantification Based on 2D T2* and 3D T1-Weighted MRI Sequences.  6th Conference Clinical Trials on Alzheimer’s Disease Abstracts November 14–16, 2013 San Diego, CA — USA. The Journal of Nutrition, Health & Aging 17(9): 774-856.

Bracoud, L., F. Lala, F. Bonneville, M. Pueyo, S. Gouttard, I. Guignot, N. Sastre, P.-J. Ousset, C. Pachai and B. Vellas (2013). The ROSAS study: Baseline MRI characteristics. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(4): P427-P428.

2012

R. McCarrie, C.G. Miller, Ph.D. X-Ray Acquisition Challenges in Clinical Trials: Challenges and Solutions Posed by the Synaflexer. OA Biomakers Global Initiative 2012, Hilton Head Island, South Carolina.

V Navarro-Compán, R Landewé, H Ahmad, C Miller, D Xu, D van der Heijde. Prediction of rate of adjucication of radiological progression in rheumatoid arthritis (RA) randomized controlled trials (RCTs) in early and established disease. Annual European Congress of Rheumatology EULAR 2012, London, United Kingdom.

Novak G, Yu HJ, Einstein S, Guthrie S, Margolin R, Bracoud L, Belaroussi B, DeCarli S, Pachai C. Choice of Threshold Hippocampal Volume as a Selection Criterion in Prodromal Alzheimer’s Disease. AAIC 2012, Vancouver, Canada.

J.Schaerer, L.Bracoud, F.Roche, HJ.Yu, B.Belaroussi, D.Xu, C.Pachai, C.DeCarli and the Alzheimer’s Disease Neuroimaging Initiative.  Validation of a multi-atlas segmentation technique for the quantification of hippocampal volume – Application to ADNI I. CTAD 2012, Monte Carlo.

L. Bracoud, B. Belaroussi, K. Lobello, D. Li, HJ. Yu, C. Pachai, B. Wyman. Correlation between DWI-ADC and clinical scores in mild to moderate Alzheimer’s disease. AAIC 2012, Vancouver, Canada.

V Navarro-Compán, D van der Heijde, H Ahmad, C Miller, R Landewé. Calculation of the smallest detectable change (SDC) of radiographic progression in clinical trials with multiple time points: the mean SDC is a valid approximation of the overall SDC. Annual European Congress of Rheumatology EULAR 2012, London, United Kingdom.

Novak G, Einstein S, Guthrie S, Margolin R, Yu HJ, Bracoud L, Belaroussi B, DeCarli S, Pachai C. Discordance for Hippocampal Atrophy and Amyloid Burden in Amnestic Mild Cognitive Impairment May Identify Distinct Subgroups of Patients. AAIC 2012, Vancouver, Canada.

HJ.Yu, L.Bracoud, J.Schaerer, D.Xu, F.Roche, B.Belaroussi, C.Pachai, C.DeCarli and the Alzheimer’s Disease Neuroimaging Initiative. Validation of a multi-atlas segmentation technique for the quantification of hippocampal volume - Application as a selection criterion in clinical trials in Alzheimer’s Disease. CTAD 2012, Monte Carlo.

J. Schaerer, B. Belaroussi, F. Roche, F. Bonnand, HJ. Yu, C. Pachai and the Alzheimer's Disease Neuroimaging Initiative. Accurate Intracranial cavity volume estimation in Mild Cognitively Impaired population using multi- atlas segmentation. AAIC 2012, Vancouver, Canada.

E DeYoe, PhD, J Voyvodic, PhD, C Elsinger, PhD (co-chair), J Petrella, MD (co-chair), H Ahmad, MD, A Buckler, MS, F Mohamed, PhD, J Pillai, MD, J Reuss, PhD, D Zaca, PhD representing The RSNA QIBA-fMRI Committee. Reproducibility of Functional MRI – Progress Towards Profile Development. ASFNR 2012, Orlando, Florida.

B. Belaroussi, F. Roche, J. Schaerer, L. Bracoud, HJ. Yu, C. Pachai and the Alzheimer's Disease Neuroimaging Initiative. Multi-atlas segmentation of the hippocampus refined with intensity-based tissue classification. AAIC 2012, Vancouver, Canada.

L. Bracoud, V. Coric, C.H. van Dyck, N. Andreasen, J. Ross, M. Brody, C. Curtis, B. Belaroussi, HJ. Yu, S. Kaplita, H. Feldman, C. Pachai and R.M. Berman. Baseline clinical scores and volumetric MRI parameters across subjects randomized in mild-to-moderate (BMS CN156-013) and predementia (BMS CN156-018) Alzheimer’s disease clinical trials of avagacestat. AAIC 2012, Vancouver, Canada.

C.G. Miller, Ph.D., B. Horvath, H.J. Yu, Ph.D., S. Jackson, MD, N. Binkley, MD. Dual Energy X-Ray Absorptiometry Body Composition: A New Phantom for Clinical Trials. ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions 2012. Kansas City , Missouri.

L. Bracoud, H. Ahmad, A. Lopez, E. Brill Almon and R. Chertkoff. Variability assessment of spleen volume measurements based on MRI sequence selection in Gaucher subjects. EWGGD 2012, Paris, France.

Yu HJ, Belaroussi B, Bracoud L, Guthrie S, Einstein S, DeCarli S, Novak G, Pachai C. Impact of Hippocampal Volume–Based Enrichment on Clinical Outcomes in Prodromal AD Trials Up to 3-Years Follow-Up. AAIC 2012, Vancouver, Canada.

2011

Belaroussi, B., L. Bracoud, et al. (2011). High-throughput and accurate segmentation of lateral ventricles and other structures using combined single atlas propagation and tissue classification: Application to ADNI and IBSR data. International Congress on Alzheimer’s Disease, Paris, France.

Bracoud, L., A. Caputo, et al. (2011). Longitudinal ADC changes in Alzheimer’s Disease in a multi-center clinical trial setting. International Congress on Alzheimer’s Disease, Paris, France.

Belaroussi, B., L. Bracoud, et al. (2011). Whole-Brain and ventricular volume change measurement in multicenter clinical trials: A feasibility study of Jacobian Integration using ADNI data. International Congress on Alzheimer’s Disease, Paris, France.

E DeYoe, J Voyvodic, CElsinger, J Petrella, H Ahmad, A Buckler, F Mohamed, J Pillai, J Reuss, D Zaca. Reproducibility of Functional MRI – Progress Towards Profile Development (QIBA Presentation at RSNA 2011)

C.G. Miller, J.P. Bilezikian, A.J. Nino, B.G. Kravitz, G. Paul, A.R. Cobitz, A.R. Northcutt, L.A. Fitzpatrick. Evaluation of QCT Cortical Hip Parameters in a Clinical Trial With Rosiglitazone:Potential for a New Study Endpoint. ASBMR 2011.

Belaroussi, B., F. Durand-Dubief, et al. (2011). FreeSurfer Reproducibility of MRI-derived measurements of longitudinal volume changes in MS subjects: Impact of change in MRI scanners. ECTRIMS, Amsterdam, The Netherlands.

CG Miller, PhD, A Brett, E Bogner, M Tan, R Cope, MB Jenkins,J Haslam, P Steiger, CW Hayes, Reproducibility of a Vertebral Deformity Tool (VDT) using an Active Shape Modeling Workflow Tool. ASBMR 2011.

Ahmad, H., C. G. Miller, et al. (2011). Blinded Reads in Rheumatoid Arthritis Clinical Trials: Adjudication Rates for Varying Thresholds Based on Change Scores of Two Readers Utilizing X-Rays of the Hands and Feet. Annual European Congress of Rheumatology EULAR 2011, London, United Kingdom.

2010

L. Bracoud, H. Ahmad, E. Brill Almon and R. Chertkoff. Measurement of spleen and liver volumes using MRI in an enzyme-replacement therapy multi-center trial on naïve patients with Gaucher Disease. European Working Group on Gaucher disease (EWGGD) 2010.

Bilezikian JP, Kravitz BG, Lewiecki EM , Miller CG, Northcutt AR, Paul G, Cobitz A, Nino AJ, Fitzpatrick LA. Effects of Rosiglitazone on Bone: Assessing QCT Parameters in a Mechanistic Study of Postmenopausal Women with Type 2 Diabetes Mellitus (Poster). American Society of Bone and Mineral Research (ASBMR), October 2010.

Elsinger C, Petrella J, Ahmad H, Barboriak D, Buchbinder B, Buckler A, Clarke G, DeYoe E, Faro S, Gupta S, Jackson E, Mohamed F, Mukundan S, Pillai J, Reuss J, Sullivan D, Tucker D, Voyvodic J, Zaca D, Zahlmann G, Advancing BOLD Functional MR Imaging Technology – Roadmap for Developing a Quantitative Imaging Biomarker Poster Presentation at RSNA 2010

2009

Haslam J, Hayes C, Ozanian T, Miller CG, Krasnow K, Cope R, Brett, A. Automatic Classification of vertebral shape based on statistical shape modeling.  Paper presented at the National Osteoporosis Foundation Meeting.  2009.

Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M; STAIR VI Consortium (contributor Ahmad H). Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke. 2009 Jul;40(7):2594-600.

2008

B. Belaroussi, L. Bracoud, F. Bonnand, F. Vincent, K. Noever and C. Pachai. Brain Atrophy Measurement in Multicenter studies: Application of Brain Boundary Shift Integral and Jacobian Integration International Conference on Alzheimer’s Disease. 24-27 June 2008, Chicago, USA.

2007

Brett A, Krasnow J, Miller CG, Haslam J, Ozanian T, van Kuijk C, Abrahams K, Cope R, Beke M, Hayes C. Automatic assessment of vertebral shape by statistical modeling on lateral radiographs. Bone and Mineral Research. 2007;22(s1):s419.

Miller CG, Brett A, Yogmas C, Dawson E, Lacey A. Reproducibility of radiographic anatomical axis measurement of the knee using a software workflow tool. Osteoarthritis and Cartilage. 2007;5(Suppl C):194.

2004

Faro SH, Haddonfield NJ, Mohamed F, Gordon N, Platek S, Williams M, Ahmad H. Functional MRI of Deception and Truth with Polygraph Correlation. Radiology Society of North America (RSNA) Abstract Proceedings. 2004;p282.

2003

Mohamed FB, Gordon NJ, Pinus A, Ahmad H, Williams M, Tracy JI, Faro SH. fMRI Study of Truth & Deception Using Classical Question Technique 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine. 2003 p. 1920

Mohamed FB, Khaled KA, Faro SH, Pinus A, Ahmad H, Williams M, Haselgrove J, Assaf B. Hippocampal Diffusion Tensor Measurements in Temporal Lobe Epilepsy 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine. 2003. p. 2227

2001

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A. Identification of biomarkers in allergy and asthma: effects of glucocorticosteriods on cell surface and soluble factors.  American Academy of Allergy, Asthma and Immunology abstract. 2001.

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A.  Phenotypic profiling in allergy and asthma: effects of glucocorticosteriods on cell surface and soluble factors.  Federation of Clinical Immunolgy Societies. 2001.

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A.   Phenotypic profiling in allergy aand asthma: effects of glucocorticosteriods on cell surface and soluble factors.  European Asthma Congress. 2001.

Miller CG, Pak J, Caminis JN. Precision of DXA measurements of the spine and total hip in adolescents. Journal of Bone and Mineral Research. 2001;16(S1):S317.

2000

Pierre H, Lacroix Z, Perrone A.  Longitudinal Patient-Centered Collection and Analysis of Clinical Data.  Proceedings. IEEE EMBS 3rd International Conference Information Technology Applications in Biomedicine. Arlington, VA. 2000, p. 316-23.

1999

Mehta MP, Eisenberg P, Schultz CJ, et. al. Computer Assisted Masked MRI Reading in a Phase III Trial of Gadolinium Texpaphyrin (Gd-Tex) in Patients with Brain Metastases. Society of Neuro-Oncology Annual Meeting. 1999.

Mehta MP, Eisenberg P, Schultz CJ, et. al. Computer Assisted Masked MRI Analysis of Volumetric Response: Implementation for A Phase III Protocol of Gadolinium Texpaphyrin (Gd-Tex) in Patients with Brain Metastases. Society of Neuro-Oncology Annual Meeting, 1999 October.

1998

Miller CG, Lyons AR, Pye DW, Blaze M, Fasano GA, Horneye S. Dual energy x-ray absorptiometry (DXA) transmission methodology in clinical trials. Drug Information Journal. 1998;32-4

Rosen C, McClung M, Gallagher C, Baldwin D, Faulkner K, Trempe J, Miller C. Heel ultrasound reference data for caucasian women in the USA. Journal of Clinical Densitometry. 1998; 1(1):107.

1997

Nord RH, Bisek JP, Miller CG. A new hydroxyapatite spine phantom. Osteoporosis International. 1997.

Miller CG, Lyons AR, Pye D, Fasano G, Horneye S. New DEXA quality control methodology in clinical trials. Journal of Bone and Mineral Research. 1997;12(S1);S5377.

1996

Miller CG, Ohlsson S, Borg J, Johnell O. Vertebral morphometry using radiographs: comparison of manual and digitized images in expert software.  Osteoporosis International. 1996;6(S1).