Clinical Trial Abstracts and Proceedings

Abstracts and Proceedings

2012

HJ.Yu, L.Bracoud, J.Schaerer, D.Xu, F.Roche, B.Belaroussi, C.Pachai, C.DeCarli and the Alzheimer’s Disease Neuroimaging Initiative. Validation of a multi-atlas segmentation technique for the quantification of hippocampal volume - Application as a selection criterion in clinical trials in Alzheimer’s Disease. CTAD 2012, Monte Carlo.

L. Bracoud, B. Belaroussi, K. Lobello, D. Li, HJ. Yu, C. Pachai, B. Wyman. Correlation between DWI-ADC and clinical scores in mild to moderate Alzheimer’s disease. AAIC 2012, Vancouver, Canada.

V Navarro-Compán, D van der Heijde, H Ahmad, C Miller, R Landewé. Calculation of the smallest detectable change (SDC) of radiographic progression in clinical trials with multiple time points: the mean SDC is a valid approximation of the overall SDC. Annual European Congress of Rheumatology EULAR 2012, London, United Kingdom.

J.Schaerer, L.Bracoud, F.Roche, HJ.Yu, B.Belaroussi, D.Xu, C.Pachai, C.DeCarli and the Alzheimer’s Disease Neuroimaging Initiative.  Validation of a multi-atlas segmentation technique for the quantification of hippocampal volume – Application to ADNI I. CTAD 2012, Monte Carlo.

V Navarro-Compán, R Landewé, H Ahmad, C Miller, D Xu, D van der Heijde. Prediction of rate of adjucication of radiological progression in rheumatoid arthritis (RA) randomized controlled trials (RCTs) in early and established disease. Annual European Congress of Rheumatology EULAR 2012, London, United Kingdom.

R. McCarrie, C.G. Miller, Ph.D. X-Ray Acquisition Challenges in Clinical Trials: Challenges and Solutions Posed by the Synaflexer. OA Biomakers Global Initiative 2012, Hilton Head Island, South Carolina.

L. Bracoud, H. Ahmad, A. Lopez, E. Brill Almon and R. Chertkoff. Variability assessment of spleen volume measurements based on MRI sequence selection in Gaucher subjects. EWGGD 2012, Paris, France.

C.G. Miller, Ph.D., B. Horvath, H.J. Yu, Ph.D., S. Jackson, MD, N. Binkley, MD. Dual Energy X-Ray Absorptiometry Body Composition: A New Phantom for Clinical Trials. ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions 2012. Kansas City , Missouri.

B. Belaroussi, F. Roche, J. Schaerer, L. Bracoud, HJ. Yu, C. Pachai and the Alzheimer's Disease Neuroimaging Initiative. Multi-atlas segmentation of the hippocampus refined with intensity-based tissue classification. AAIC 2012, Vancouver, Canada.

J. Schaerer, B. Belaroussi, F. Roche, F. Bonnand, HJ. Yu, C. Pachai and the Alzheimer's Disease Neuroimaging Initiative. Accurate Intracranial cavity volume estimation in Mild Cognitively Impaired population using multi- atlas segmentation. AAIC 2012, Vancouver, Canada.

Novak G, Einstein S, Guthrie S, Margolin R, Yu HJ, Bracoud L, Belaroussi B, DeCarli S, Pachai C. Discordance for Hippocampal Atrophy and Amyloid Burden in Amnestic Mild Cognitive Impairment May Identify Distinct Subgroups of Patients. AAIC 2012, Vancouver, Canada.

Novak G, Yu HJ, Einstein S, Guthrie S, Margolin R, Bracoud L, Belaroussi B, DeCarli S, Pachai C. Choice of Threshold Hippocampal Volume as a Selection Criterion in Prodromal Alzheimer’s Disease. AAIC 2012, Vancouver, Canada.

Yu HJ, Belaroussi B, Bracoud L, Guthrie S, Einstein S, DeCarli S, Novak G, Pachai C. Impact of Hippocampal Volume–Based Enrichment on Clinical Outcomes in Prodromal AD Trials Up to 3-Years Follow-Up. AAIC 2012, Vancouver, Canada.

L. Bracoud, V. Coric, C.H. van Dyck, N. Andreasen, J. Ross, M. Brody, C. Curtis, B. Belaroussi, HJ. Yu, S. Kaplita, H. Feldman, C. Pachai and R.M. Berman. Baseline clinical scores and volumetric MRI parameters across subjects randomized in mild-to-moderate (BMS CN156-013) and predementia (BMS CN156-018) Alzheimer’s disease clinical trials of avagacestat. AAIC 2012, Vancouver, Canada.

E DeYoe, PhD, J Voyvodic, PhD, C Elsinger, PhD (co-chair), J Petrella, MD (co-chair), H Ahmad, MD, A Buckler, MS, F Mohamed, PhD, J Pillai, MD, J Reuss, PhD, D Zaca, PhD representing The RSNA QIBA-fMRI Committee. Reproducibility of Functional MRI – Progress Towards Profile Development. ASFNR 2012, Orlando, Florida.

2011

E DeYoe, J Voyvodic, CElsinger, J Petrella, H Ahmad, A Buckler, F Mohamed, J Pillai, J Reuss, D Zaca. Reproducibility of Functional MRI – Progress Towards Profile Development (QIBA Presentation at RSNA 2011)

CG Miller, PhD, A Brett, E Bogner, M Tan, R Cope, MB Jenkins,J Haslam, P Steiger, CW Hayes, Reproducibility of a Vertebral Deformity Tool (VDT) using an Active Shape Modeling Workflow Tool. ASBMR 2011.

C.G. Miller, J.P. Bilezikian, A.J. Nino, B.G. Kravitz, G. Paul, A.R. Cobitz, A.R. Northcutt, L.A. Fitzpatrick. Evaluation of QCT Cortical Hip Parameters in a Clinical Trial With Rosiglitazone:Potential for a New Study Endpoint. ASBMR 2011.

Belaroussi, B., L. Bracoud, et al. (2011). Whole-Brain and ventricular volume change measurement in multicenter clinical trials: A feasibility study of Jacobian Integration using ADNI data. International Congress on Alzheimer’s Disease, Paris, France.

Bracoud, L., A. Caputo, et al. (2011). Longitudinal ADC changes in Alzheimer’s Disease in a multi-center clinical trial setting. International Congress on Alzheimer’s Disease, Paris, France.

Belaroussi, B., L. Bracoud, et al. (2011). High-throughput and accurate segmentation of lateral ventricles and other structures using combined single atlas propagation and tissue classification: Application to ADNI and IBSR data. International Congress on Alzheimer’s Disease, Paris, France.

Ahmad, H., C. G. Miller, et al. (2011). Blinded Reads in Rheumatoid Arthritis Clinical Trials: Adjudication Rates for Varying Thresholds Based on Change Scores of Two Readers Utilizing X-Rays of the Hands and Feet. Annual European Congress of Rheumatology EULAR 2011, London, United Kingdom.

Belaroussi, B., F. Durand-Dubief, et al. (2011). FreeSurfer Reproducibility of MRI-derived measurements of longitudinal volume changes in MS subjects: Impact of change in MRI scanners. ECTRIMS, Amsterdam, The Netherlands.

2010

Bilezikian JP, Kravitz BG, Lewiecki EM , Miller CG, Northcutt AR, Paul G, Cobitz A, Nino AJ, Fitzpatrick LA. Effects of Rosiglitazone on Bone: Assessing QCT Parameters in a Mechanistic Study of Postmenopausal Women with Type 2 Diabetes Mellitus (Poster). American Society of Bone and Mineral Research (ASBMR), October 2010.

L. Bracoud, H. Ahmad, E. Brill Almon and R. Chertkoff. Measurement of spleen and liver volumes using MRI in an enzyme-replacement therapy multi-center trial on naïve patients with Gaucher Disease. European Working Group on Gaucher disease (EWGGD) 2010.

Elsinger C, Petrella J, Ahmad H, Barboriak D, Buchbinder B, Buckler A, Clarke G, DeYoe E, Faro S, Gupta S, Jackson E, Mohamed F, Mukundan S, Pillai J, Reuss J, Sullivan D, Tucker D, Voyvodic J, Zaca D, Zahlmann G, Advancing BOLD Functional MR Imaging Technology – Roadmap for Developing a Quantitative Imaging Biomarker Poster Presentation at RSNA 2010

2009

Haslam J, Hayes C, Ozanian T, Miller CG, Krasnow K, Cope R, Brett, A. Automatic Classification of vertebral shape based on statistical shape modeling.  Paper presented at the National Osteoporosis Foundation Meeting.  2009.

Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M; STAIR VI Consortium (contributor Ahmad H). Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke. 2009 Jul;40(7):2594-600.

2008

B. Belaroussi, L. Bracoud, F. Bonnand, F. Vincent, K. Noever and C. Pachai. Brain Atrophy Measurement in Multicenter studies: Application of Brain Boundary Shift Integral and Jacobian Integration International Conference on Alzheimer’s Disease. 24-27 June 2008, Chicago, USA.

2007

Miller CG, Brett A, Yogmas C, Dawson E, Lacey A. Reproducibility of radiographic anatomical axis measurement of the knee using a software workflow tool. Osteoarthritis and Cartilage. 2007;5(Suppl C):194.

Brett A, Krasnow J, Miller CG, Haslam J, Ozanian T, van Kuijk C, Abrahams K, Cope R, Beke M, Hayes C. Automatic assessment of vertebral shape by statistical modeling on lateral radiographs. Bone and Mineral Research. 2007;22(s1):s419.

2004

Faro SH, Haddonfield NJ, Mohamed F, Gordon N, Platek S, Williams M, Ahmad H. Functional MRI of Deception and Truth with Polygraph Correlation. Radiology Society of North America (RSNA) Abstract Proceedings. 2004;p282.

2003

Mohamed FB, Khaled KA, Faro SH, Pinus A, Ahmad H, Williams M, Haselgrove J, Assaf B. Hippocampal Diffusion Tensor Measurements in Temporal Lobe Epilepsy 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine. 2003. p. 2227

Mohamed FB, Gordon NJ, Pinus A, Ahmad H, Williams M, Tracy JI, Faro SH. fMRI Study of Truth & Deception Using Classical Question Technique 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine. 2003 p. 1920

2001

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A.   Phenotypic profiling in allergy aand asthma: effects of glucocorticosteriods on cell surface and soluble factors.  European Asthma Congress. 2001.

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A.  Phenotypic profiling in allergy and asthma: effects of glucocorticosteriods on cell surface and soluble factors.  Federation of Clinical Immunolgy Societies. 2001.

Alters S, Perrone A, Cheal K, Cromer R, Snapper J, Kantor A. Identification of biomarkers in allergy and asthma: effects of glucocorticosteriods on cell surface and soluble factors.  American Academy of Allergy, Asthma and Immunology abstract. 2001.

Miller CG, Pak J, Caminis JN. Precision of DXA measurements of the spine and total hip in adolescents. Journal of Bone and Mineral Research. 2001;16(S1):S317.

2000

Pierre H, Lacroix Z, Perrone A.  Longitudinal Patient-Centered Collection and Analysis of Clinical Data.  Proceedings. IEEE EMBS 3rd International Conference Information Technology Applications in Biomedicine. Arlington, VA. 2000, p. 316-23.

1999

Mehta MP, Eisenberg P, Schultz CJ, et. al. Computer Assisted Masked MRI Reading in a Phase III Trial of Gadolinium Texpaphyrin (Gd-Tex) in Patients with Brain Metastases. Society of Neuro-Oncology Annual Meeting. 1999.

Mehta MP, Eisenberg P, Schultz CJ, et. al. Computer Assisted Masked MRI Analysis of Volumetric Response: Implementation for A Phase III Protocol of Gadolinium Texpaphyrin (Gd-Tex) in Patients with Brain Metastases. Society of Neuro-Oncology Annual Meeting, 1999 October.

1998

Rosen C, McClung M, Gallagher C, Baldwin D, Faulkner K, Trempe J, Miller C. Heel ultrasound reference data for caucasian women in the USA. Journal of Clinical Densitometry. 1998; 1(1):107.

Miller CG, Lyons AR, Pye DW, Blaze M, Fasano GA, Horneye S. Dual energy x-ray absorptiometry (DXA) transmission methodology in clinical trials. Drug Information Journal. 1998;32-4

1997

Miller CG, Lyons AR, Pye D, Fasano G, Horneye S. New DEXA quality control methodology in clinical trials. Journal of Bone and Mineral Research. 1997;12(S1);S5377.

Nord RH, Bisek JP, Miller CG. A new hydroxyapatite spine phantom. Osteoporosis International. 1997.

1996

Miller CG, Ohlsson S, Borg J, Johnell O. Vertebral morphometry using radiographs: comparison of manual and digitized images in expert software.  Osteoporosis International. 1996;6(S1).