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Serum

Adiponectin // Acrp30

Adiponectin, also called adipocyte complement-related protein of 30kDa (Acrp30), is a collagen-like protein predominantly synthesized and secreted by adipocytes (Scherer et al., 1995). Adiponectin is the most abundant adipokine in blood and exists under three forms: dimers, hexamers or higher order multimers (respectively called low-, middle-, and high-molecular weight forms) (Pajvani et al., 2003). Among its role in lipid and glucose metabolism regulation, adiponectin is also described for its involvement in inflammatory processes (Ouchi et al., 2011).

25OH VitD // 25-Hydroxyvitamin D

Vitamin D exists in two primary forms, Vitamin D3 (cholecalciferol) as the major circulating form and Vitamin D2 (ergocalciferol). To exert their molecular action, these two forms are twice hydroxylated, on carbon 25 and subsequently on carbon 1. The single hydroxylated Vitamin D: 25OH VitD2/3, can be used as marker to assess the vitamin D level in patients (Christakos et al., 2010; Norman, 2008; Ross, A. Catharine 2011).

1,25OH VitD // 1,25-Dihydroxyvitamin D

1,25-Dihydroxyvitamin D is the most active metabolite of vitamin D and circulates at pmol levels, whereas the precursor 25OH Vit D circulates at nmol levels. 1,25-OH Vit D is formed upon ultraviolet exposure and two hydroxylations, in the liver and in kidneys (Szymczak and Pawliczak, 2015). To measure this highly lipophilic molecule the assay has to combine a selective immuno-extraction followed by quantitation with an immunoassay (Hollis and Horst, 2007).

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