Please Wait...

Aβ 1-42 // Beta Amyloid 1-42

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Amyloid peptides are produced during neuronal activity. Amyloid precursor protein is first cleaved by β secretase-1 (BACE-1) and then by γ secretase. When the concentration of Aβ1-42 is high, there is an increased propensity of amyloid plaques formation (Braak et al., 2013; Lührs et al., 2005). Accumulation of extracellular plaques of amyloid is one of the features of Alzheimer's disease, detection of these plaques in PET imaging and indirectly with reduced Aβ1-42 levels in cerebrospinal fluid is indicative in the diagnosis of Alzheimer's disease(Blennow et al., 2015; Palmqvist S et al., 2014).

Bioclinica Lab employs a manual sandwich ELISA for the measurement of Aβ1-42 in human cerebrospinal fluid.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Join Bioclinica in a live #Xtalks webinar 10/31 exploring challenges & benefits of different sourcing models to man… https://t.co/kRYNc1Z3gj
bioclinica (2 hours ago)
Bioclinica contributions toward advancement of #Alzheimer's disease research & therapies showcased in 8 different s… https://t.co/j96UN9568o
bioclinica (8 hours ago)
Bioclinica’s Joby John reflects on the #SCDM2018 Annual Conference & being a part a thriving community of clinical… https://t.co/c70gH5kJo9
bioclinica (Yesterday)
RT @bioclinica: Our own Jeff Heilbraun is in Tokyo nxt wk to lead a discussion at DIA’s Cardiac Safety Workshop in Japan. Jeff will give an…
bioclinica (Yesterday)
RT @Xtalks: Trends in #SitePayments: Insight into How CROs Can Gain a Competitive Edge This webinar will focus on the latest market researc…
bioclinica (Yesterday)
Great connecting w @bioclinica clients Odonate Therapeutics, Eisai, & PCI Biotech, at #ESMO18 #oncology… https://t.co/4wKrLof8e6
bioclinica (Yesterday)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner