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Anti-CCP // Antibody to Cyclic Citrullinated Peptide

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The posttranslational protein modification which consists in conversion of peptidyl-arginine to peptidyl citrulline (citrullination) is an important process in the initiation of rheumatoid arthritis (Rantapää-Dahlqvist et al., 2003). Production of anti-CCP antibodies can lead to formation of immunogenic complex and, in the end, to rheumatoid arthritis (van Venrooij et al., 2011). Anti-CCP antibodies are one of the biomarkers used for the diagnosis of early rheumatoid arthritis.

Bioclinica Lab employs an automated electro-chemiluminescent assay for the semi-quantitative measurement of Anti-CCP antibodies in serum.

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