Please Wait...

BAFF // B Cell Activating Factor

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

B-cell Activating Factor (BAFF) is a member of the TNF family and induces B cell proliferation and differentiation. The soluble form of BAFF is a 152aa with a single disulfide bond (Moore et al., 1999).

This cytokine is also called tumor necrosis factor ligand superfamily member 13b (TNFSF13b), B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) among other names.

BAFF binds to 3 receptors: TACI, BCMA and BAFF-R/BR-3. The third one binds only BAFF but the two others also bind APRIL (A PRoliferation Inducing Ligand from the TNF family ligand)(Wei et al.2015). BAFF is one of the major factors implicated in the maturation and survival of B cells (Cancro, 2004). Mice overexpressing BAFF develop autoimmune manifestations (autoantibodies, germinal center formation…)(Mackay et al., 1999). Elevated BAFF levels are found in patient with several autoimmune diseases (Fabris et al., 2010; Moura et al., 2011; Toubi et al., 2006)

BAFF levels have also been found to decrease in Sjögren’s syndrome and juvenile idiopathic arthritis under different therapeutics (Glaesener et al., 2014; Pollard et al., 2013; St Clair et al., 2013)

 

BAFF assay is a solid phase enzyme linked immunoassay which has been validated in the laboratory for measurement in human serum.

 

Cancro, M.P. (2004). The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Immunol. Rev. 202, 237–249.

Fabris, M., Grimaldi, F., Villalta, D., Picierno, A., Fabro, C., Bolzan, M., De Vita, S., and Tonutti, E. (2010). BLyS and April serum levels in patients with autoimmune thyroid diseases. Autoimmun. Rev. 9, 165–169.

Glaesener, S., Quách, T.D., Onken, N., Weller-Heinemann, F., Dressler, F., Huppertz, H.-I., Thon, A., and Meyer-Bahlburg, A. (2014). Distinct Effects of Methotrexate and Etanercept on the B Cell Compartment in Patients With Juvenile Idiopathic Arthritis. Arthritis Rheumatol. Hoboken Nj 66, 2590–2600.

Mackay, F., Woodcock, S.A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J., and Browning, J.L. (1999). Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations. J. Exp. Med. 190, 1697–1710.

Moore, P.A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D.W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., et al. (1999). BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator. Science 285, 260–263.

Moura, R.A., Cascao, R., Perpetuo, I., Canhao, H., Vieira-Sousa, E., Mourao, A.F., Rodrigues, A.M., Polido-Pereira, J., Queiroz, M.V., Rosario, H.S., et al. (2011). Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival. Rheumatology 50, 278–282.

Pollard, R.P.E., Abdulahad, W.H., Vissink, A., Hamza, N., Burgerhof, J.G.M., Meijer, J.M., Visser, A., Huitema, M.G., Spijkervet, F.K.L., Kallenberg, C.G.M., et al. (2013). Serum levels of BAFF, but not APRIL, are increased after rituximab treatment in patients with primary Sjögren’s syndrome: data from a placebo-controlled clinical trial. Ann. Rheum. Dis. 72, 146–148.

St Clair, E.W., Levesque, M.C., Luning Prak, E.T., Vivino, F.B., Alappatt, C.J., Spychala, M.E., Wedgwood, J., McNamara, J., Moser Sivils, K.L., Fisher, L., et al. (2013a). Rituximab Therapy for Primary Sjögren’s Syndrome: An Open-Label Clinical Trial and Mechanistic Analysis. Arthritis Rheum. 65, 1097–1106.

Toubi, E., Gordon, S., Kessel, A., Rosner, I., Rozenbaum, M., Shoenfeld, Y., and Zuckerman, E. (2006). Elevated serum B-Lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: Association with autoimmunity. J. Autoimmun. 27, 134–139.

Wei, F., Chang, Y., and Wei, W.(2015) The role of BAFF in the progression of rheumatoid arthritis. Cytokine.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Join Bioclinica in a live #Xtalks webinar 10/31 exploring challenges & benefits of different sourcing models to man… https://t.co/kRYNc1Z3gj
bioclinica (3 hours ago)
Bioclinica contributions toward advancement of #Alzheimer's disease research & therapies showcased in 8 different s… https://t.co/j96UN9568o
bioclinica (9 hours ago)
Bioclinica’s Joby John reflects on the #SCDM2018 Annual Conference & being a part a thriving community of clinical… https://t.co/c70gH5kJo9
bioclinica (Yesterday)
RT @bioclinica: Our own Jeff Heilbraun is in Tokyo nxt wk to lead a discussion at DIA’s Cardiac Safety Workshop in Japan. Jeff will give an…
bioclinica (Yesterday)
RT @Xtalks: Trends in #SitePayments: Insight into How CROs Can Gain a Competitive Edge This webinar will focus on the latest market researc…
bioclinica (Yesterday)
Great connecting w @bioclinica clients Odonate Therapeutics, Eisai, & PCI Biotech, at #ESMO18 #oncology… https://t.co/4wKrLof8e6
bioclinica (Yesterday)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner