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BAP // Bone Alkaline Phosphatase

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Alkaline phosphatase (ALP) catalyzes the hydrolysis of phosphomonoesters with alcohol and inorganic phosphate release. In human body, there are four ALP isoenzymes coded by four gene loci: tissue nonspecific ALP or liver/bone/kidney ALP, placental ALP, germ cell ALP and intestinal ALP. Liver, bone and kidney ALP are coded by the same gene but differs in posttranslational modification (Weiss et al., 1986). Bone ALP (BAP) is localized on the surface of osteoblasts and associated with bone formation. BAP can be released and measured in serum (Garnero and Delmas, 1993). A rise in BAP levels in serum is indicative of an increasing bone turnover.

Bioclinica Lab employs an automated chemiluminescent immunoassay for the measurement of BAP in serum.

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