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Bone TRAP // Bone Tartrate Resistant Acid Phosphatase

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Tartrate-resistant acid phosphatase produced in bone-resorbing osteoclasts (TRACP 5b), or Bone Trap, is one of the two isoforms of TRACP (Janckila et al., 2003). The two isoforms differ in their content in sialic acid and TRACP 5a has a reduced activity at pH 6.0 (Halleen et al., 2000; Nenonen et al., 2005). Variation in serum levels of TRACP 5b isoform reflects modification in the bone resorption rate (Halleen et al., 2001).

Bioclinica Lab employs an immune-fixed enzyme activity assay designed to measure specific activity of TRACP 5b activity in human serum. To differentiate the two isoforms, the immunoassay used in the laboratory is a pH selective activity assay.

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