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C1, 2C // Type I and Type II Collagen 3/4C Short

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

In osteoarthritis, cartilage tissue is progressively degraded with denaturation of type II collagen by collagenases. MMP-1, MMP-8 and MMP-13, collagenases are known to cleave type II collagen, and are believed to act first on a unique site in the triple helix, producing approximately 3/4 and ¼ lengths denatured α chain (Billinghurst et al., 1997). These neo-epitopes can be measured in serum of osteoarthritis patients.

Bioclinica Lab employs a manual competitive immunoassay designed for the measurement in serum matrix of the carboxy-terminus of the ¾ piece fragments of type I and II collagens containing the neo-epitope generated by collagenase activity.

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