Please Wait...

COMP // Cartilage Oligomeric Matrix Protein

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Cartilage oligomeric matrix protein (COMP) is also called thrombospondin-5 (TSP-5). COMP possess a RGD motif which allow interaction with integrins (Tan et al., 2009). COMP can bind to chondrocytes (the only cell type found in cartilage) and promote early stages of chondrogenic differentiation of mesenchymal stem cells, in association with bone morphogenic protein-2 (BMP-2)(Chen et al., 2005). Serum COMP is elevated in patients with diagnosed OA (level of evidence grade C) (Hoch et al., 2011).

Bioclinica Lab employs a manual immunoassay validated in the laboratory for measurement of COMP in serum and synovial fluid.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

With many clinical trials slowed or terminated, investments in new technologies are difficult. Yet, a #CTMS with a… https://t.co/VRIhWWf4tE
Bioclinica (5 days ago)
With Bioclinica #CTMS, sponsors & CROs have access to a full-featured, scalable system - a single, centralized sour… https://t.co/7ACrv8cvuF
Bioclinica (1 week ago)
Now available: a DIY #EDC solution. From study start-up to close-out, Bioclinica EDC Solo is an efficient, cost-eff… https://t.co/vFhC7ITfZV
Bioclinica (2 weeks ago)
Reduce the number of user requirement iterations and UAT findings during the #IRT build process. With the agile app… https://t.co/TJt2sZlrFP
Bioclinica (2 weeks ago)
Don't compromise with manual systems and spreadsheets. As an entry-level system with phased implementation, Bioclin… https://t.co/qIpi1MESXw
Bioclinica (3 weeks ago)
According to our recent poll, 45% of respondents had neither a #CTMS nor an #eTMF system, while only 24% had both.… https://t.co/l4dKC7pBQo
Bioclinica (3 weeks ago)