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CREAT // Creatinine

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Produced by muscle metabolism, creatinine is a degradation product of creatine phosphate and is essentially eliminated through the kidneys (Onuigbo and Agbasi, 2015). Creatinine metabolism is constant in one person and, in non-pathological situation, has a production rate equivalent to the renal extraction rate. Its concentration in serum is then dependent of the elimination capacity of the kidneys. Serum creatinine is the oldest and the most commonly used marker for estimating the glomerular filtration rate (Perrone et al., 1992). In order to minimize variation induced by liquid intake, numerous urinary biomarkers are normalized with the creatinine value in urine.

Bioclinica Lab employs an automated colorimetric assay based on the Jaffé method for the measurement of Creatinine in serum or in urine.

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