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CXCL10 // C-X-C motif chemokine 10

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

CXCL10 is a 10 kDa protein and is also known as Interferon γ-induced protein 10 (IP-10) or small-inducible cytokine B10. This cytokine is implicated in the cell migration of leukocytes and its expression is dependent on interferon γ (IFN γ) in numerous cell types (neutrophils, monocytes, T lymphocytes, endothelial cells, fibroblast, keratinocytes, and thyrocytes among others)(Antonelli et al., 2014).

The CXCR3 receptor also binds the IFN γ inducible chemokines CXCL9 and CXCL11 and the platelet-derived chemokines CXCL4 and CXCL4L1. CXCL10 have been found to be implicated in several diseases, from solid and hematopoietic tumors to inflammatory or neurodegenerative disorders (Van Raemdonck et al., 2015).

 

CXCL10 assay is a solid phase enzyme linked immunoassay which has been validated in the laboratory for measurement in human serum.

 

Antonelli, A., Ferrari, S.M., Giuggioli, D., Ferrannini, E., Ferri, C., and Fallahi, P. (2014). Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmun. Rev. 13, 272–280.

Van Raemdonck, K., Van den Steen, P.E., Liekens, S., Van Damme, J., and Struyf, S. (2015). CXCR3 ligands in disease and therapy. Cytokine Growth Factor Rev. 26, 311–327.

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