Please Wait...

CXCL10 // C-X-C motif chemokine 10

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

CXCL10 is a 10 kDa protein and is also known as Interferon γ-induced protein 10 (IP-10) or small-inducible cytokine B10. This cytokine is implicated in the cell migration of leukocytes and its expression is dependent on interferon γ (IFN γ) in numerous cell types (neutrophils, monocytes, T lymphocytes, endothelial cells, fibroblast, keratinocytes, and thyrocytes among others)(Antonelli et al., 2014).

The CXCR3 receptor also binds the IFN γ inducible chemokines CXCL9 and CXCL11 and the platelet-derived chemokines CXCL4 and CXCL4L1. CXCL10 have been found to be implicated in several diseases, from solid and hematopoietic tumors to inflammatory or neurodegenerative disorders (Van Raemdonck et al., 2015).

 

CXCL10 assay is a solid phase enzyme linked immunoassay which has been validated in the laboratory for measurement in human serum.

 

Antonelli, A., Ferrari, S.M., Giuggioli, D., Ferrannini, E., Ferri, C., and Fallahi, P. (2014). Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmun. Rev. 13, 272–280.

Van Raemdonck, K., Van den Steen, P.E., Liekens, S., Van Damme, J., and Struyf, S. (2015). CXCR3 ligands in disease and therapy. Cytokine Growth Factor Rev. 26, 311–327.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Integration of #eTMF and #CTMS eliminates redundancies, improves workflows & enables greater study control. Join th… https://t.co/dnqwBLTvy3
Bioclinica (3 days ago)
Save time and minimize risk with Bioclinica’s Clinical Trial Management System (CTMS) Starter Package. A full-featu… https://t.co/MW4e031hXf
Bioclinica (4 days ago)
Bioclinica’s Resale #IRT offers flexible configuration, delivery in weeks not months, & an affordable, predictable… https://t.co/vVjH0VLpSv
Bioclinica (2 weeks ago)
The Clinical Trial Management System (CTMS) Starter Package from Bioclinica saves time and minimizes the risk often… https://t.co/VRGMjKlzL4
Bioclinica (2 weeks ago)
We are pleased to announce @directbiologics will leverage Bioclinica's IRT solution for its EXIT #COVID19 study. Th… https://t.co/Iun6UrL6Bt
Bioclinica (3 weeks ago)
The integration of Bioclinica CTMS & eTMF with SharePoint enable teams to work in familiar programs & remote work a… https://t.co/QRBt1sdljh
Bioclinica (3 weeks ago)