Please Wait...

CXCL13 // C-X-C motif chemokine 13

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

CXCL13 (also known as BCA-1 or BLC) is a 10.46kDa protein of 88 residues. Its receptor, CXCR5, is expressed by TFH cells in the follicle (TFH outside the follicle do not express CXCR5). For example, CXCR5 is expressed in the TFH cells which help B cells to differentiate in long lived plasma cells (Tangye et al., 2013).

Blocking the internalization of CXCR5 in mouse, with an anti-CXCL13 antibody, results in impairment of B cell homing in secondary lymphoid organ. It also attenuates symptoms in a model of autoimmune encephalomyelitis (Klimatcheva et al., 2015).

Elevated levels of CXCL13 in serum are detected in several inflammatory diseases such as rheumatoid arthritis, primary Sjörgren’s syndrome and for neuroinflammation (Alvarez et al., 2013; Jones et al., 2014; Kowarik et al., 2012; Nocturne et al., 2015).

 

CXCL13 assay is a solid phase enzyme linked immunoassay which has been validated in the laboratory for measurement in human serum.

 

Alvarez, E., Piccio, L., Mikesell, R.J., Klawiter, E.C., Parks, B.J., Naismith, R.T., and Cross, A.H. (2013). CXCL13 is a Biomarker of Inflammation in Multiple Sclerosis, Neuromyelitis Optica, and Other Neurological Conditions. Mult. Scler. Houndmills Basingstoke Engl. 19, 1204–1208.

Jones, J.D., Hamilton, B.J., Challener, G.J., de Brum-Fernandes, A.J., Cossette, P., Liang, P., Masetto, A., Ménard, H.A., Carrier, N., Boyle, D.L., et al. (2014). Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels. Arthritis Res. Ther. 16, R103.

Klimatcheva, E., Pandina, T., Reilly, C., Torno, S., Bussler, H., Scrivens, M., Jonason, A., Mallow, C., Doherty, M., Paris, M., et al. (2015). CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol. 16, 6.

Kowarik, M.C., Cepok, S., Sellner, J., Grummel, V., Weber, M.S., Korn, T., Berthele, A., and Hemmer, B. (2012). CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation. J. Neuroinflammation 9, 93.

Nocturne, G., Seror, R., Fogel, O., Belkhir, R., Boudaoud, S., Saraux, A., Larroche, C., Le Guern, V., Gottenberg, J.E., and Mariette, X. (2015). CXCL13 and CCL11 serum levels and lymphoma and disease activity in primary Sjögren Syndrome: CXCL13, CCL11 and disease activity in pSS. Arthritis Rheumatol. n/a – n/a.

Tangye, S.G., Ma, C.S., Brink, R., and Deenick, E.K. (2013). The good, the bad and the ugly — TFH cells in human health and disease. Nat. Rev. Immunol. 13, 412–426.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Join Bioclinica in a live #Xtalks webinar 10/31 exploring challenges & benefits of different sourcing models to man… https://t.co/kRYNc1Z3gj
bioclinica (2 hours ago)
Bioclinica contributions toward advancement of #Alzheimer's disease research & therapies showcased in 8 different s… https://t.co/j96UN9568o
bioclinica (8 hours ago)
Bioclinica’s Joby John reflects on the #SCDM2018 Annual Conference & being a part a thriving community of clinical… https://t.co/c70gH5kJo9
bioclinica (Yesterday)
RT @bioclinica: Our own Jeff Heilbraun is in Tokyo nxt wk to lead a discussion at DIA’s Cardiac Safety Workshop in Japan. Jeff will give an…
bioclinica (Yesterday)
RT @Xtalks: Trends in #SitePayments: Insight into How CROs Can Gain a Competitive Edge This webinar will focus on the latest market researc…
bioclinica (Yesterday)
Great connecting w @bioclinica clients Odonate Therapeutics, Eisai, & PCI Biotech, at #ESMO18 #oncology… https://t.co/4wKrLof8e6
bioclinica (Yesterday)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner