Please Wait...

CXCL8/IL8 // C-X-C motif chemokine 8 / Interleukin 8

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

CXCL8 was the first characterized chemokine and was initially named IL-8. CXCL8, expressed by activated Th17 helper cells, attracts and activates neutrophils cells (Walz et al., 1987).

CXCL8 bind two different receptors: CXCR1 and CXCR2. CXCR1 is specific for CXCL8 and CXCR2 binds also CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL7. Under physiological conditions, CXCL8 exists as monomers and dimers and both forms bind the receptors but the monomeric forms have a better ability to induce CXCR1 phosphorylation, desensitization and internalization (whereas both forms induce these actions for CXCR2). Dimerization of CXCL8 is then implicated in the regulation of inflammatory response (Nasser et al., 2009).

 

CXCL8-IL8 assay is a solid phase enzyme linked immunoassay which has been validated in the laboratory for measurement in human serum.

 

Nasser, M.W., Raghuwanshi, S.K., Grant, D.J., Jala, V.R., Rajarathnam, K., and Richardson, R.M. (2009). Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J. Immunol. Baltim. Md 1950 183, 3425–3432.

Walz, A., Peveri, P., Aschauer, H., and Baggiolini, M. (1987). Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem. Biophys. Res. Commun. 149, 755–761.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Ck out best-of-breed trial #technologies & services: #RTSM, #esource, #EDC, site & patient #payments, global site… https://t.co/DJCNZ9C1uq
Bioclinica (Yesterday)
ICYMI: A discussion on recently released FDA draft guidance on assessment of blood pressure response in… https://t.co/7fmrkhhuQd
Bioclinica (Yesterday)
Our CIO & EVP Tech Gavin Nichols adds to #digitaltransformation discussion at #CMAsummit18 : W genomics & precision… https://t.co/oisqWvGJXC
Bioclinica (3 days ago)
Greetings from Tokyo where @bioclinica's Japan. China & US locations R@DrugInfoAssn DIA Japan. Discuss region-spec… https://t.co/HMzmFwA9pm
Bioclinica (5 days ago)
Reminder to join us in a live #Xtalks webinar tomorrow 11/6 on Electronic Data Capture (EDC). Everything clinical t… https://t.co/WS0L3QQnPv
Bioclinica (2 weeks ago)
Meet with representatives of Bioclinica's Japan, China & US locations at DIA Japan. Angel Y., Hidenori Seshimo & Er… https://t.co/j1alTH8oBm
Bioclinica (2 weeks ago)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner