Please Wait...

IGFBP-3 // Insulin-Like Growth Factor Binding Protein 3

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The majority of Insulin Like Growth Factors (IGFs) in serum is complexed with IGF Binding Proteins (IGFBP) and acid-labile subunit (ALS). Six IGFBPs have been cloned and identified. IGFBP3 has the highest binding capacity for IGF-1 and it prolonged its high life in serum. GFBPs in serum regulate the endocrine actions of IGFs by modulating bioavailable IGF (Mohan and Baylink, 2002). IGFBPs constitute a "buffer" capable of limiting the effect of a rise in IGF concentration (which could result in hypoglycemia) (Ranke, 2015). IGFBP3, through its binding with IGF-1, can also have a role in cancer cell growth and proliferation through a possible potentiation of IGF-1 signaling (Baxter, 2014).

Bioclinica Lab employs a high sensitive manual sandwich immunoassay for measurement of IGFBP3 in serum.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Ck out best-of-breed trial #technologies & services: #RTSM, #esource, #EDC, site & patient #payments, global site… https://t.co/DJCNZ9C1uq
Bioclinica (Yesterday)
ICYMI: A discussion on recently released FDA draft guidance on assessment of blood pressure response in… https://t.co/7fmrkhhuQd
Bioclinica (Yesterday)
Our CIO & EVP Tech Gavin Nichols adds to #digitaltransformation discussion at #CMAsummit18 : W genomics & precision… https://t.co/oisqWvGJXC
Bioclinica (3 days ago)
Greetings from Tokyo where @bioclinica's Japan. China & US locations R@DrugInfoAssn DIA Japan. Discuss region-spec… https://t.co/HMzmFwA9pm
Bioclinica (5 days ago)
Reminder to join us in a live #Xtalks webinar tomorrow 11/6 on Electronic Data Capture (EDC). Everything clinical t… https://t.co/WS0L3QQnPv
Bioclinica (2 weeks ago)
Meet with representatives of Bioclinica's Japan, China & US locations at DIA Japan. Angel Y., Hidenori Seshimo & Er… https://t.co/j1alTH8oBm
Bioclinica (2 weeks ago)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner