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IL-1β // Interleukin 1 beta

Biomarker Therapeutic Areas: 
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Interleukin 1β (IL-1β) belongs to the IL-1 family. In this family IL-1α and IL-1β bind to the same receptor and have identical biological activity. IL-1β is secreted, circulate in the bloodstream, and have a systemic activity, when IL-1α is generally associated with the producing cells plasma membrane and acts more locally (Sims and Smith, 2010). Active Il-1β is produced by cleavage ofpro-IL-1β by caspase-1 or neutrophil protease. IL-1β is secreted by innate immune cells and is a pro-inflammatory cytokine highly produced in several inflammatory diseases such as familial Mediterranean fever, Pyogenic arthritis pyoderma gangaenosum and acne, crystal‑induced arthropathies, rheumatoid arthritis and osteoarthritis (Schett et al., 2015).

Bioclinica Lab employs a high sensitive manual sandwich immunoassay for measurement of IL-1β in serum.

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