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MMP-1 // Pro-Matrix Metalloproteinase 1

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The MMPs family comprises at least 24 different MMPs with high sequence similarity in their catalytic domains. MMPs are synthetized as pro-enzymes which are inactive until removal of their pro-domain (Löffek et al., 2011; Nagase and Woessner, 1999). MMP-1 is also called Collagenase 1 or Fibroblast collagenase and is believed to degrade type I, II and III fibrillary collagens in the extracellular matrix. MMP-1 is implicated in different remodeling process in connective tissues as well as in inflammation and immunity (Parks et al., 2004). MMP-1 expression also facilitates the spread of colon cancer or gastric cancer (Dey et al., 2014; Murray et al., 1996).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of pro-MMP1 in serum.

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