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MMP-13 // Pro-Matrix Metalloproteinase 13

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The MMPs family comprises at least 24 different MMPs with high sequence similarity in their catalytic domains. MMPs are synthetized as pro-enzymes which are inactive until removal of their pro-domain (Löffek et al., 2011; Nagase and Woessner, 1999). MMP-13 is also called collagenase 3 and cleaves the interstitial collagens types I, II and III with a high potency against collagen of type II (the major component of cartilage)(Leeman et al., 2002). MMP-13 have also a high activity against gelatin (44 times more efficient than MMP-1 and, 3 to 8 times more than MMP-8) and against cartilage aggrecan (Fosang et al., 1996; Knäuper et al., 1996).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of pro-MMP-13 in synovial fluid.

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