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MMP-3 // Active and Pro-Matrix Metalloproteinase 3

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The MMPs family comprises at least 24 different MMPs with high sequence similarity in their catalytic domains. MMPs are synthetized as pro-enzymes which are inactive until removal of their pro-domain (Löffek et al., 2011; Nagase and Woessner, 1999). Matrix metalloproteinase 3 (MMP-3, also known as stromelysin-1), secreted by chondrocytes and synovial cells, activates other proteases and has a broad substrate specificity for degrading extracellular matrix components (fibronectin, laminin, elastin, collagen IV, and proteoglycans)(Kim and Hwang, 2011; Murphy et al., 1991). Higher serum or synovial fluid levels of MMP-3 have been found to be correlated with disease progression in osteoarthritis and rheumatoid arthritis (Lohmander et al., 2005; Ma et al., 2015). MMP3 is also implicated in matrix degeneration in neurodegeneration (Kim and Hwang, 2011).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of total MMP-3 in serum or in synovial fluid.

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