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MMP-8 // Total Matrix Metalloproteinase 8

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

The MMPs family comprises at least 24 different MMPs with high sequence similarity in their catalytic domains. MMPs are synthetized as pro-enzymes which are inactive until removal of their pro-domain (Löffek et al., 2011; Nagase and Woessner, 1999). MMP-8 is also known as collagenase-2 or neutrophil collagenase and is implicated in the degradation of a wide range of substrates: type I, II and III collagens, proteoglycans, fibronectin, fibrinogen, angiotensin I, substance P, Angiotensin, CXCL10 and many others (Lenglet et al., 2013; Van Lint and Libert, 2006). MMP-8 is associated with numerous pathologies and processes such as cancer progression, atherosclerosis, innate immunity or inflammatory disorders (Laxton et al., 2009; Van Lint and Libert, 2006).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of total MMP-8 in synovial fluid.

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