Please Wait...

NTX-I // N-Terminal Crosslinked Telopeptide of Type I Collagen

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

In bone, type I collagen constitute 90% of the organic matrix. Markers of bone resorption in serum or urine can be used to assess changes in bone resorption in various bone diseases or under treatment (Naylor and Eastell, 2012). Cross linked amino-terminal collagen (NTx-I) are peptides derived from the degradation of collagen I. Measurement of these peptides in urine or serum provide information about the bone resorption rate. The specific assay for NTx peptides have been developed in the nineties and urine values have been found to correlate with HPLC measurements of urinary hydroxyproline or pyridinoline in patients with Paget's disease (Hanson et al., 1992). Different studies have since shown the pertinence of NTx measurement for assessing bone resorption rate in other diseases (Bettica et al., 2002; Clemens et al., 1997; Garnero et al., 1996).

Bioclinica Lab employs a manual sandwich immunoassay for measurement in urine (associated with creatinine values) or in serum.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Ck out best-of-breed trial #technologies & services: #RTSM, #esource, #EDC, site & patient #payments, global site…
Bioclinica (Yesterday)
ICYMI: A discussion on recently released FDA draft guidance on assessment of blood pressure response in…
Bioclinica (Yesterday)
Our CIO & EVP Tech Gavin Nichols adds to #digitaltransformation discussion at #CMAsummit18 : W genomics & precision…
Bioclinica (3 days ago)
Greetings from Tokyo where @bioclinica's Japan. China & US locations R@DrugInfoAssn DIA Japan. Discuss region-spec…
Bioclinica (5 days ago)
Reminder to join us in a live #Xtalks webinar tomorrow 11/6 on Electronic Data Capture (EDC). Everything clinical t…
Bioclinica (2 weeks ago)
Meet with representatives of Bioclinica's Japan, China & US locations at DIA Japan. Angel Y., Hidenori Seshimo & Er…
Bioclinica (2 weeks ago)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner