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PGE2 // Prostaglandin E2

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Prostaglandin E2, derived from arachinoic acid, is implicated in a wide variety of process: paracrine mediator of the Luteinizing Hormone surge as well as stimulating inflammation in osteoarthritis and rheumatoid arthritis (Duffy, 2015; Park et al., 2006). In osteoarthritis, its synthesis is promoted indirectly (through Cyclooxygenase-2 upregulation) by pro-inflammatory cytokines such as IL-1β and TNF-α (Martel-Pelletier et al., 2003).

Bioclinica Lab employs a competitive immunoassay for measurement of PGE2 in synovial fluid.

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