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Survivin

Biomarker Therapeutic Areas: 
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Survivin is the smallest member of the Inhibitor of Apoptosis Protein (IAP) family. The eight members of the IAPs family contain Baculoviral IAP Repeat (BIR) motifs. Initially identified in bacculovirus, BIR motif is a sequence of approximately 70 amino acids that coordinates a zinc ion (through histidine and cystine residues)(Srinivasula and Ashwell, 2008). Survivin expression was detected in different solid cancers and lymphomas (Ambrosini et al., 1997). Its role in cancer metastasis and progression as well, as its role in cell division or stems cell maintenance, have been well studied since (Altieri, 2015; Athanasoula et al., 2014). The therapeutic potential of surviving inhibition has also been investigated in clinical trials (Athanasoula et al., 2014).

Bioclinica Lab employs a manual sandwich ELISA for survivin measurement in serum.

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