Please Wait...

T-tau // Total Tau

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Tau neurofibrillary tangles are one of the two neuropathological features of Alzheimer's disease (with Amyloid plaques). Through its interaction with microtubule protein, Tau is implicated in the neuronal integrity, cellular signaling and axonal transport (Weingarten et al., 1975). In Alzheimer's Disease, there is an increase in Tau phosphorylation which lead to higher cytosolic concentration of Tau (no longer bound to microtubules protein) and subsequently to formation of neurofibrillary tangles (Ballatore et al., 2007; Brandt et al., 2005). An increase in total Tau levels in cerebrospinal fluid is helpful for the diagnosis of Alzheimer's disease (Fagan and Holtzman, 2010; Shaw et al., 2009).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of Total Tau in human cerebrospinal fluid.

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Ck out best-of-breed trial #technologies & services: #RTSM, #esource, #EDC, site & patient #payments, global site… https://t.co/DJCNZ9C1uq
Bioclinica (21 hours ago)
ICYMI: A discussion on recently released FDA draft guidance on assessment of blood pressure response in… https://t.co/7fmrkhhuQd
Bioclinica (21 hours ago)
Our CIO & EVP Tech Gavin Nichols adds to #digitaltransformation discussion at #CMAsummit18 : W genomics & precision… https://t.co/oisqWvGJXC
Bioclinica (2 days ago)
Greetings from Tokyo where @bioclinica's Japan. China & US locations R@DrugInfoAssn DIA Japan. Discuss region-spec… https://t.co/HMzmFwA9pm
Bioclinica (4 days ago)
Reminder to join us in a live #Xtalks webinar tomorrow 11/6 on Electronic Data Capture (EDC). Everything clinical t… https://t.co/WS0L3QQnPv
Bioclinica (2 weeks ago)
Meet with representatives of Bioclinica's Japan, China & US locations at DIA Japan. Angel Y., Hidenori Seshimo & Er… https://t.co/j1alTH8oBm
Bioclinica (2 weeks ago)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner