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TGF-β1 // Transforming Growth Factor beta 1

Biomarker Therapeutic Areas: 
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Transforming Growth Factor β1 (TGF-β1), an homodimer of two 12.5 kDa subunits, belongs to the TGF β superfamily which comprises Bone Morphogenetic Proteins, activins, inhibins, growth differentiation factors and myostatin. There are three isoforms of TGF β (TGF-β1, TGF-β2 and TGF-β3) encoded by three different genes. Even if these three isoforms interact with the same receptor (heterodimer of TGFR-1 and TGFR-2), they are implicated in slightly different biological functions (Lafyatis, 2014). TGF-β1 is secreted together with its latency associated pro-peptide (LAP), is active only after a complete posttranslational process and releasing from LAP association (which can be, for example, provoked by mechanical stimulation) (Hinz, 2015). TGF-β family is implicated in numerous biological process such as regulation of cell proliferation, migration and adhesion of differentiated cells, extracellular matrix production, induction of stromal cytokine, fibrosis and in modifying tumor micro-environment (Massagué, 2012).

Bioclinica Lab employs a manual sandwich immunoassay specific for TGF-β1 measurement in serum.

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