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UcOC // Undercarboxylated Osteocalcin

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Osteocalcin (OC), also called bone γ-carboxyglutamic acid protein (BGP), is a 49 residues containing non-collagenous protein found in bone and dental tissues. OC is produced by osteoblasts and is a vitamin K dependent protein implicated in bone formation. Initially identified as a protein limiting bone formation, new functions such as implication in glucose metabolism, reproduction and cognition have been identified since (Ducy et al., 1996; Zoch et al., 2016). OC binds to hydroxyapatite and a fraction of the newly synthetized protein is then released in blood circulation. The binding to hydroxyapatite is impaired when OC is decarboxylated (Price et al., 1981). In addition to this source of variation in biological activities, intact OC is rapidly cleaved by proteolytic enzymes and is unstable in vitro. In serum, several proteolytic fragments of OC are present and the N-terminal-mid fragment (N-Mid) is the most abundant immunoreactive form (about 30% of total OC)(Garnero et al., 1994).

Bioclinica Lab employs an automated electro-chemiluminescence immunoassay which recognizes the N-Mid OC. The assay for UcOC measurement is a twostep assay, which comprises an affinity depletion of carboxylated OC in samples with hydroxyapatite followed by an immunoassay for the measurement of the non-bound OC.

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