Please Wait...

Gender and age-related changes of thigh muscle fat infiltration in subjects of the OAI MRI cohort without radiographic osteoarthritis

*Yu, H.J. PhD, ***Tan, C. MS, ***Yan, Z. MS, **Miller C.G. PhD, *Fuerst T. PhD, *Engelke K. PhD, ***Metaxas, D. PhD
* BioClinica, Inc., Princeton NJ and Germany  **Alacrita LLC, Cambridge MA  ***Rutgers University, Piscataway NJ

BACKGROUND
Increasing age is a known risk factor for knee osteoarthritis (OA), which results in increased muscle weakness and decreased mobility. Inter-muscular and intra-muscular adipose tissues are defined as the adipose tissue visible between muscle groups and muscle fibers, respectively. The quantities of inter-muscular adipose tissue (inter-MAT), intra-muscular adipose tissue (intra-MAT) and muscle in the thigh reflect adverse metabolic effects and muscle function.

OBJECTIVES

  1. To investigate gender differences age related changes of muscle and adipose tissue volume in the thigh.
  2. Propose a robust and automatic algorithm for the quantitative assessment of volume of thigh muscle, inter- and intra-muscular fat; Overcome the time-consuming and operator-dependent problems in traditional manual analysis, especially towards 3D datasets.

METHODS
An automatic quantification framework consisting of 5 major steps was developed (Fig 1): 1) intensity inhomogeneity correction; 2) subcutaneous adipose tissue (SAT) removal; 3) tissue labeling for bone, marrow, fat and muscle; 4) inter- and intra-MAT classification; 5) measurement of volume. Fig 2 shows T1 weighted MRI of middle aged and elderly men and women together with the segmentation results.

The OAI database was queried for subjects with the bilateral KLG scores of 0 or 1, did not progress in 48 months, and mid-thigh axial T1-weighted MRIs (15 contiguous slices, 5 mm slice thickness) at baseline. 234 subjects out of 4,796 participants were identified, and 226 subjects (76 male, 150 female; age: 45-77) were processed on their left leg after image QC. Volume (15 slices) was calculated for total thigh muscle, SAT, and inter- and intra-MAT.

RESULTS
Correlations with age for muscle volume normalized for BMI, for the sum of inter- and intra-MAT and separately for intra-MAT both normalized for muscle volume are shown in Fig 3.

CONCLUSION
In healthy subjects of the OAI cohort, BMI adjusted age-related muscle volume decreased more in female than male.  The muscular fat to muscle volume ratio did not significantly change with age, although there was an increasing trend in both female and male groups. The proposed framework provides an automated approach for quantitative thigh tissue assessment in T1 weighted MRI images. Ongoing development efforts include reduction of operator interactions to correct segmentation defects.

SPONSOR: BioClinica Inc.
DISCLOSURE STATEMENT: None; ACKNOWLEDGMENT: None CORRESPONDENCE ADDRESS: huijing.yu@bioclinica.com

Author: 

LEARN MORE OR SPEAK WITH OUR EXPERTS

CONTACT US
Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

Bioclinica contributions toward advancement of #Alzheimer's disease research & therapies showcased in 8 different s… https://t.co/j96UN9568o
bioclinica (1 hour ago)
Bioclinica’s Joby John reflects on the #SCDM2018 Annual Conference & being a part a thriving community of clinical… https://t.co/c70gH5kJo9
bioclinica (19 hours ago)
RT @bioclinica: Our own Jeff Heilbraun is in Tokyo nxt wk to lead a discussion at DIA’s Cardiac Safety Workshop in Japan. Jeff will give an…
bioclinica (Yesterday)
RT @Xtalks: Trends in #SitePayments: Insight into How CROs Can Gain a Competitive Edge This webinar will focus on the latest market researc…
bioclinica (Yesterday)
Great connecting w @bioclinica clients Odonate Therapeutics, Eisai, & PCI Biotech, at #ESMO18 #oncology… https://t.co/4wKrLof8e6
bioclinica (Yesterday)
Our own Jeff Heilbraun is in Tokyo nxt wk to lead a discussion at DIA’s Cardiac Safety Workshop in Japan. Jeff will… https://t.co/BX6wzXctMm
bioclinica (3 days ago)

Latest Blogs:

Dr. Joby John
Transformational Trends in Investigator Site Payments
Clinical Supply Chain Success: Leveraging Technology
Blood pressure monitor
Prescription box
Latin America: Benefit from the Right Partner