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Authored Publications

Authored Publications


Jeff Heilbraun Integrations of Cardiac Endpoints in International Clinical Trials. May 2020.

Marietta Herrmann, Klaus Engelke, Regina Ebert, Sigrid Müller-Deubert, Maximilian Rudert, Fani Ziouti, Franziska Jundt, Dieter Felsenberg and Franz Jakob Interactions between Muscle and Bone—Where Physics Meets Biology in Biomolecules March 2020 


Ishiguro N, Tanaka Y, Yamanaka H, Yoneda T, Ohira T, Okubo N, Genant HK, van der Heijde D, Takeuchi T. Efficacy of denosumab with regard to bone destruction in prognostic subgroups of Japanese rheumatoid arthritis patients from the phase II DRIVE study. Rheumatology (Oxford). 2019 [Epub ahead of print] PubMed PMID: 30602032.


Wang L, Museyko O, Su Y, Brown K, Yang R, Zhang Y, Duanmu Y, Guo Z, Zhang W, Yan D, Cheng X, Engelke K. QCT of the femur: Comparison between QCTPro CTXA and MIAF Femur. Bone. 2018 Oct 17. [Epub ahead of print] PubMed PMID: 30342226.

Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators. Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma. N Engl J Med. 2017;376(11):1015-1026. PMCID: PMC5635424.

Winston A, Post FA, DeJesus E, Podzamczer D, Di Perri G, Estrada V, Raffi F, Ruane P, Peyrani P, Crofoot G, Mallon PWG, Castelli F, Yan M, Cox S, Das M, Cheng A, Rhee MS. Tenofovir alafenamide plus emtricitabine versus abacavir plus lamivudine for treatment of virologically suppressed HIV-1-infected adults: a randomised, double-blind, active-controlled, non-inferiority phase 3 trial. Lancet HIV. 2018 [Epub ahead of print] PubMed PMID: 29475804.

DeJesus E, Haas B, Segal-Mauer S, Ramgopal M, Mills A, Margot N, Liu YP, Makadzange T, McCallister S. Superior Efficacy and Improved Renal and Bone Safety After Switching From a Tenofovir Disoproxil Fumarate (TDF)- to a Tenofovir Alafenamide (TAF)-based Regimen Through 96 Weeks of Treatment. AIDS Res Hum Retroviruses. 2018 Jan 25. [Epub ahead of print]


Basselerie H, Bracoud L, Zeestraten E, Bouguen E, Kiyasova V, Pueyo M, Cognard C, Dumas H, Gramada R, Ousset PJ, Vellas B, Bonneville F.  Incident Cerebral Microbleeds Detected by Susceptibility Weight-Imaging Help to Identify Patients with Mild Cognitive Impairment Progressing to Alzheimer's Disease.  J Alzheimers Dis. 2017;60(1):253-262. doi: 10.3233/JAD-170470. PMID: 28826188.

Mark Tengowski, DVM, PhD, Scientific Director, Bioclinica; Thomas Fuerst, PhD, Chief Science Officer, Bioclinica, and Claude B Sirlin, UC San Diego Medical Center and UC San Diego Liver Imaging Group. Magnetic resonance imaging fatty liver changes following surgical, lifestyle or drug treatments in obese, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis subjects. Journal of Imaging Medicine, September 2017.

Tran JQ, Hartung JP, Olson AD, Mendzelevski B, Timony GA, Boehm MF, Peach RJ, Gujrathi S, Frohna PA.  Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study.  Clin Pharmacol Drug Dev. 2017 Aug 7. doi: 10.1002/cpdd.383. PMID: 28783871.

Bente L Langdahl, Cesar Libanati, Daria B Crittenden, Michael A Bolognese, Jacques P Brown, Nadia S Daizadeh, Eva Dokoupilova, Klaus Engelke, Joel S Finkelstein, Harry K Genant, Stefan Goemaere, Lars Hyldstrup, Esteban Jodar-Gimeno, Tony M Keaveny, David Kendler, Peter Lakatos, Judy Maddox, Jorge Malouf, Fabio E Massari, Jose Fernando Molina, Maria Rosa Ulla, Andreas Grauer.  Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.  The Lancet, 2017, ISSN 0140-6736.

Ronald L Van Heertum, Robert Scarimbolo, John G Wolodzko, Barbara Klencke, Richard Messmann, Feza Tunc, Levi Sokol, Rajan Agarwal, James A Strafaci, and Michael O’Neal. Lugano 2014 Criteria for Assessing FDG-PET/CT in Lymphoma: An Operational Approach for Clinical Trials. Drug Design, Development and Therapy 11 (2017): 1719–1728. PMC. Web. 18 July 2017.

Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O’Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. van der Ploeg.  Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.  MOLMET505, 13 July 2017.

Luana Pesco Koplowitz, Gary Gintant, Robert Ward, Dominique Heon, Muriel Saulnier, Jeff Heilbraun. Drug-Induced Cardiac Abnormalities in Premature Infants and Neonates.  American Heart Journal, 2017. ISSN 0002-8703.

Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, Sokol L, Agarwal R, Strafaci JA, O'Neal M.  Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials.  Dovepress.  13 June 2017 Volume 2017:11 Pages 1719—1728.

Prof Kim N Chi, MD, Celestia S Higano, MD, Brent Blumenstein, PhD, Prof Jean-Marc Ferrero, MD, James Reeves, MD, Susan Feyerabend, MD, Gwenaelle Gravis, MD, Prof Axel S Merseburger, MD, Prof Arnulf Stenzl, MD, Andries M Bergman, MD, Som D Mukherjee, MD, Pawel Zalewski, MD, Prof Fred Saad, MD, Cindy Jacobs, MD, Prof Martin Gleave, MD, Prof Johann S de Bono, MD. Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial. The Lancet Oncology. Volume 18, Issue 4, April 2017, Pages 473–485.

Ketter N, Brashear HR, Bogert J, Di J, Miaux Y, Gass A, Purcell DD, Barkhof F, Arrighi HM. Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer's Disease Patients. J Alzheimers Dis. 2017;57(2):557-573. doi: 10.3233/JAD-160216.

J Bellmunt, M.D., Ph.D., R de Wit, M.D., Ph.D., D J. Vaughn, M.D., Y Fradet, M.D., J Lyun Lee, M.D., Ph.D., L Fong, M.D., N J. Vogelzang, M.D., M A. Climent, M.D., D P. Petrylak, M.D., T K. Choueiri, M.D., A Necchi, M.D., W Gerritsen, M.D., Ph.D., H Gurney, M.D., D I. Quinn, M.D., Ph.D., S Culine, M.D., Ph.D., C N. Sternberg, M.D., Y Mai, Ph.D., C H. Poehlein, M.D., R F. Perini, M.D., and D F. Bajorin, M.D., for the KEYNOTE-045 Investigators. Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma. N Engl J Med 2017; 376:1015-1026March 16, 2017DOI: 10.1056/NEJMoa1613683.

Jacob Elkins, Roland Veltkamp, Joan Montaner, S Claiborne Johnston, Aneesh B Singhal, Kyra Becker, Maarten G Lansberg, Weihua Tang, Ih Chang, Kumar Muralidharan, Sarah Gheuens, Lahar Mehta, Mitchell S V Elkind.  Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial.  Lancet Neurol March 2017; 16: 217–26.

Edwin DeJesus, MD, Moti Ramgopal, MD, Gordon Crofoot, MD, Peter Ruane, MD, Anthony LaMarca, MD, Anthony Mills, MD, Claudia T Martorell, MD, Joseph de Wet, MD, Hans-Jürgen Stellbrink, MD, Jean-Michel Molina, MD, Frank A Post, MD, Ignacio Pérez Valero, MD, Danielle Porter, PhD, YaPei Liu, PhD, Andrew Cheng, MD, Erin Quirk, MD, Devi SenGupta, MD, Dr Huyen Cao, MD. Switching from efavirenz, emtricitabine, and tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study. The Lancet HIV. 2 March 2017.

Ken Y. Yoneda, Judith R. Scranton, Michael A. Cadogan, Vanessa Tassell, Sashi Nadanaciva, Keith D. Wilner, Nicholas S. Stollenwerk.  Interstitial Lung Disease Associated With Crizotinib in Patients With Advanced Non–Small Cell Lung Cancer: Independent Review of Four PROFILE Trials.  March 6, 2017.  DOI:

Ken Y. Yoneda, Judith R. Scranton, Michael A. Cadogan, Vanessa Tassell, Sashi Nadanaciva, Keith D. Wilner, Nicholas S. Stollenwerk. Interstitial Lung Disease Associated With Crizotinib in Patients With Advanced Non–Small Cell Lung Cancer: Independent Review of Four PROFILE Trials. Clinical Lung Cancer. DOI: 10.1016/j.cllc.2017.03.004.

Mende, Christian W. and Giles, Thomas D. and Bharucha, David B. and Ferguson, William G. and Mallick, Madhuja and Patel, Mehul D.  Efficacy of nebivolol-valsartan single-pill combination in obese and nonobese patients with hypertension.  The Journal of Clinical Hypertension.  DOI: 10.1111/jch.12965.  January 11, 2017.


Noel G McElvaney, MD, Jonathan Burdon, MD, Mark Holmes, MD, Allan Glanville, MD, Peter A B Wark, MD, Philip J Thompson, MD, Paul Hernandez, MD, Jan Chlumsky, MD, Helmut Teschler, MD, Joachim H Ficker, MD, Niels Seersholm, MD, Prof Alan Altraja, MD, Riitta Mäkitaro, MD, Joanna Chorostowska-Wynimko, MD, Marek Sanak, MD, Paul I Stoicescu, MD, Eeva Piitulainen, MD, Oliver Vit, MSc, Marion Wencker, MD, Michael A Tortorici, PhD, Michael Fries, PhD, Jonathan M Edelman, MD, Kenneth R Chapman, MD on behalf of the RAPID Extension Trial Group.  Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).  1 December 2016.  DOI:

Serge Gauthier, MD, Howard H Feldman, MD, Lon S Schneider, MD, Gordon K Wilcock, DM, Giovanni B Frisoni, MD, Jiri H Hardlund, MD, Hans J Moebius, MD, Peter Bentham, MBChB, Karin A Kook, PhD, Damon J Wischik, PhD, Bjoern O Schelter, Charles S Davis, PhD, Roger T Staff, PhD, Luc Bracoud, MSc, Kohkan Shamsi, MD, John M D Storey, Charles R Harrington, PhD, Claude M Wischik, MBBS.  Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. 15 November 2016. DOI:

Anita Boyapati, Jérôme Msihid, Stefano Fiore, Janet van Adelsberg, Neil M. H. Graham and Jennifer D. Hamilton. Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate: a biomarker study of MOBILITY. Arthritis Research & Therapy. 2016 18:225. DOI: 10.1186/s13075-016-1132-9.

Robert R. Ford, Robert W. Ford, Michael O'Neal, Brad S. Kahl, Ling Chen, Mihaela Munteanu & Bruce D. Cheson (2016): Investigator and independent review committee exploratory assessment and verification of tumor response in a non-Hodgkin lymphoma study, Leukemia & Lymphoma, DOI: 10.1080/10428194.2016.1233535.

Felicia Cosman, M.D., Daria B. Crittenden, M.D., Jonathan D. Adachi, M.D., Neil Binkley, M.D., Edward Czerwinski, M.D., Serge Ferrari, M.D., Lorenz C. Hofbauer, M.D., Edith Lau, M.D., E. Michael Lewiecki, M.D., Akimitsu Miyauchi, M.D., Cristiano A.F. Zerbini, M.D., Cassandra E. Milmont, Ph.D., Li Chen, Ph.D., Sc.D., Judy Maddox, D.O., Paul D. Meisner, Pharm.D., Cesar Libanati, M.D., and Andreas Grauer, M.D. Romosozumab Treatment in Postmenopausal Women with Osteoporosis. N Engl J Med 2016; 375:1532-1543 October 20, 2016. DOI: 10.1056/NEJMoa1607948.

Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CAF, Hu M, Harris AG, Fitzpatrick LA, Cosman F, Christiansen C, for the ACTIVE Study Investigators. Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With OsteoporosisA Randomized Clinical Trial. JAMA. 2016;316(7):722-733. doi:10.1001/jama.2016.11136.

HK Genant MD, K Engelke PhD, MA Bolognese MD, C Mautalen MD, JP Brown MD, C Recknor MD, S Goemaere MD, T Fuerst PhD, Y-C Yang PhD, A Grauer MD, C Libanati MD.  Effects of Romosozumab Compared with Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women with Low Bone Mass.  JBMR, 3 August 2016.

CG Miller, CC Bogado, AJ Nino, AR Northcutt, HJ Yu, EM Lewiecki, G Paul, AR Cobitz, MJ Wooddella, JP Bilezikian, LA Fitzpatrick.  Evaluation of Quantitative Computed Tomography Cortical Hip Quadrant in a Clinical Trial With Rosiglitazone: A Potential New Study Endpoint.  Journal of Clinical Densitometry.

C Tan, K Li, Z Yan, D Yang, S Zhang, HJ Yu, K Engelke, C Miller, D Metaxas.  A Detection-driven and Sparsity-constrained Deformable Model for Fascia Lata Labeling and Thigh Inter-muscular Adipose Quantification.  Computer Vision and Image Understanding.  11 March 2016.

Philip G Conaghan, Mikkel Østergaard, Michael A Bowes, Chunying Wu, Thomas Fuerst, Désirée van der Heijde, Fedra Irazoque-Palazuelos, Oscar Soto-Raices, Pawel Hrycaj, Zhiyong Xie, Richard Zhang, Bradley T Wyman, John D Bradley, Koshika Soma, Bethanie Wilkinson.  Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques.  Ann Rheum Dis.  25 January 2016.


Guttmann CR, Rousset M, Roch JA, Hannoun S, Durand-Dubief F, Belaroussi B, Cavallari M, Rabilloud M, Sappey-Marinier D, Vukusic S, Cotton F. Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study. Multiple Sclerosis Journal. 2015 Sep 11. [Epub ahead of print]

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M. Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials. Drug Design, Development and Therapy 2015:9 5215–5223.

Coric V, Salloway S, H. van Dyck C, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM. Targetting Prodromal Alzheimer Disease with Avagacestat A Randomized Clinical Trial.  JAMA Neurol 2015, Sept 28. [Epub ahead of print]

Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical Use of Quantitative Computed Tomography-Based Finite Element Analysis of the Hip and Spine in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part II. J Clin Densitom. 2015 Jul-Sep;18(3):359-92.

Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Schousboe JT. Clinical Use of Quantitative Computed Tomography (QCT) of the Hip in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part I. J Clin Densitom. 2015 Jul-Sep;18(3):338-58

Shepherd JA, Schousboe JT, Broy SB, Engelke K, Leslie WD. Executive Summary of the 2015 ISCD Position Development Conference on Advanced Measures From DXA and QCT: Fracture Prediction Beyond BMD. J Clin Densitom. 2015 Jul-Sep;18(3):274-86

Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Shousboe JT. Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III. J Clin Densitom. 2015 Jul-Sep;18(3):393-407

Sibon I, Tourdias T, Felix S, Asselineau J, Bracoud L, Vivot A, Rouanet F, Renou P, Orgogozo JM, Dousset V. Magnetisation transfer parameters and stroke outcome. J Clin Neurosci. 2015 Jun;22(6):1012-7.

Krueger D, Libber J, Sanfilippo J, Yu HJ, Horvath B, Miller CG, Binkley N.  A DXA Whole Body Composition Cross-Calibration Experience: Evaluation With Humans, Spine, and Whole Body Phantoms.  J Clin Densitom. 2015 Jun 9. pii: S1094-6950(15)00041-4. doi: 10.1016/j.jocd.2015.04.003. [Epub ahead of print]

Kufner A, Wouters A, Bracoud L, Laage R, Schneider A, Schäbitz W, Hermier M, Thijs V, Fiebach JB, on behalf of the AXIS2 investigators.  Infarct Volume-Based Subgroup Selection in Acute Ischemic Stroke Trials. Stroke, May 2015.

Beck TJ, Fuerst T, Gaither KW, Sutradhar S, Levine AB, Hines T, Yu CR, Williams R, Mirkin S, Chines AA. The effects of bazedoxifene on bone structural strength evaluated by hip structure analysis. Bone. April 23, 2015. Volume 77, Pages 115–119.


Schmidt ME, Chiao P, Klein G, Matthews D, Thurfjell L, Cole PE, Margolin R, Landau S, Foster NL, Mason NS, De Santi S, Suhy J, Koeppe RA, Jagust W; Alzheimer's Disease Neuroimaging Initiative. The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability in longitudinal data. Alzheimers Dement. 2014 Nov 24. P1-19.

Geiger MJ, Mehta C, Turner JR, Arbet-Engels C, Hantel S, Hirshberg B, Koglin J, Mendzelevski B, Sager PT, Shapiro D, Stewart M, Todaro TG, and Gaydos B. Clinical Development Approaches and Statistical Methodologies to Prospectively Assess the Cardiovascular Risk of New Antidiabetic Therapies for Type 2 Diabetes. 2014 Therapeutic Innovation & Regulatory Science 1-15.

Ahmad H, Berzin TM, Yu HJ, Huang CS, Mishkin DS. Central endoscopy reads in inflammatory bowel disease clinical trials: The role of the imaging core lab. Gastroenterol Rep. 2014 Aug;2(3):201-6.

Hill DL, Schwarz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, Maguire P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang H, Wolz R, Stephenson D. Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease. Alzheimers Dement. 2014 Jul;10(4):421-9.

Yan Z, Zhang S, Tan C, Qin H, Belaroussi B, Yu HJ, Miller C, Metaxas DN.  Atlas-Based Liver Segmentation and Hepatic Fat-Fraction Assessment for Clinical Trials.  DOI: 10.1016/j.compmedimag.2014.05.012.

Hitt DM, Belabassi Y, Suhy J, Berkman CE, Thompson CM. Chemoenzymatic resolution of rac-malathion. Tetrahedron Asymmetry. 2014 Apr 15;25(6-7):529-533.

Opherk C, Gonik M, Duering M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, Liem M, Boon EM, Pescini F, Pachai C, Bracoud L, Müller-Myhsok B, Meitinger T, Rost N, Pantoni L, Oberstein SL, Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Rosand J, Chabriat H, Dichgans M. Genome-Wide Genotyping Demonstrates a Polygenic Risk Score Associated With White Matter Hyperintensity Volume in CADASIL. Stroke. 2014 Feb 27. [Epub ahead of print]


Chabriat H, Maeder P, Gass A, Michel P, Bracoud L, Hennerici MG. Results of the PERFORM magnetic resonance imaging study. J Neurol. 2013 Dec;260(12):3071-6. PMID: 24078046 [PubMed - in process]

Barakos J, Sperling R, Salloway S, Jack C, Gass A, Fiebach JB, Tampieri D, Melançon D, Miaux Y, Rippon G, Black R, Lu Y, Brashear HR, Arrighi HM, Morris KA, Grundman M. MR imaging features of amyloid-related imaging abnormalities. AJNR Am J Neuroradiol. 2013 Oct;34(10):1958-65.

Braddock M, Heilbraun J, Mendzelevski B. Cardiovascular safety and hemodynamic considerations in oncology drug development -- webinar highlights October 10th 2012Expert Opin Drug Saf. 2013 Sep;12(5):783-91. doi: 10.1517/14740338.2013.797407. Epub 2013 May 8. PMID: 23651420

Duering M, Csanadi E, Gesierich B, Jouvent E, Hervé D, Seiler S, Belaroussi B, Ropele S, Schmidt R, Chabriat H, Dichgans M. Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease. Brain. 2013 Sep;136(Pt 9):2717-26. doi: 10.1093/brain/awt184. Epub 2013 Jul 17. PMID: 23864274

Vingara LK, Yu HJ, Wagshul ME, Serafin D, Christodoulou C, Pelczer I, Krupp LB, Maletic-Savatic M. Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis. Neuroimage. 2013 Jun 7. PMID: 23751863.

Henriksen K, Wang Y, Sørensen MG, Barascuk N, Suhy J, Pedersen JT, Duffin KL, Dean RA, Pajak M, Christiansen C, Zheng Q, Karsdal MA. An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function. PLoS One. 2013 May 22;8(5).

Sager P, Heilbraun J, Turner JR, Gintant G, Geiger MJ, Kowey PR, Mansoor GA, Mendzelevski B, Michelson EL, Stockbridge N, Weber MA, White WB. Assessment of drug-induced increases in blood pressure during drug development: report from the Cardiac Safety Research Consortium. Am Heart J. 2013 Apr;165(4):477-88. doi: 10.1016/j.ahj.2013.01.002.

Navarro-Compán V, van der Heijde D, Ahmad HA, Miller CG, Wolterbeek R, Landewé R.  Measurement error in the assessment of radiographic progression in rheumatoid arthritis (RA) clinical trials: the smallest detectable change (SDC) revisited.  Ann Rheum Dis. 2013 Apr 20. [Epub ahead of print] PMID: 23606704

Jouvet JC, Thomas L, Thomson V, Yanes M, Journe C, Morelec I, Bracoud L, Durupt F, Giammarile F, Berthezene Y. Whole-body MRI with diffusion-weighted sequences compared with 18 FDG PET-CT, CT and superficial lymph node ultrasonography in the staging of advanced cutaneous melanoma: a prospective study. J Eur Acad Dermatol Venereol. 2013 Jan 18. doi: 10.1111/jdv.12078. [Epub ahead of print] PMID: 23331931

Navarro-Compán V, Landewé R, Ahmad HA, Miller CG, Xu D, Wolterbeek R, van der Heijde D. Rate of adjudication of radiological progression in rheumatoid arthritis randomized controlled trials depending on preset limits of agreement: a pooled analysis from 15 randomized trials.  Rheumatology (Oxford). 2013 Jan 16. Epub 2013 Jan 16. PMID: 23329683

Munzinger U, Guggi T, Kaptein B, Persoon M, Valstar E, Doets HC. A titanium plasma-sprayed cup with and without hydroxyapatite-coating: a randomised radiostereometric study of stability and osseointegration. Hip Int. 2013 Jan 16:0. doi: 10.5301/HIP.2013.10598. [Epub ahead of print] PMID: 23329538


Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, Decarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR Jr. Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2012 Oct 27. doi:pii: S1552-5260(12)02379-5. 10.1016/j.jalz.2012.06.004. Epub 2012 Oct 27. PMID: 23110865

Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G, Colby S, Rollin L, Dockens R, Pachai C, Portelius E, Andreasson U, Blennow K, Soares H, Albright C, Feldman HH, Berman RM. Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease. Archives of Neurology 2012 Aug 13:1-12

F. Durand-Dubief, B. Belaroussi, J.P. Armspach, M. Dufour, S. Roggerone, S. Vukusic, S. Hannoun, D. Sappey-Marinier, C. Confavreux and F. Cotton. Reliability of Longitudinal Brain Volume Loss Measurements between 2 Sites in Patients with Multiple Sclerosis: Comparison of 7 Quantification Techniques. American Journal of Neuroradiology. July 2012.

Vellas B, Hampel H, Rougé-Bugat ME, Grundman M, Andrieu S, Abu-Shakra S, Bateman R, Berman R, Black R, Carrillo M, Donohue M, Mintun M, Morris J, Petersen R, Thomas RG, Suhy J, Schneider L, Seely L, Tariot P, Touchon J, Weiner M, Sampaio C, Aisen P; Task Force Participants. Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology. J Nutr Health Aging. 2012 Apr;16(4):339-45.

Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The ORACAL trial. J Bone Miner Res. 2012 Mar 21. 27(8):1821-1829

Sperling R, Salloway S, Brooks DJ, Tampieri D, Barakos J, Fox NC, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Lieberburg I, Arrighi HM, Morris KA, Lu Y, Liu E, Gregg KM, Brashear HR, Kinney GG, Black R, Grundman M. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol. 2012 Mar;11(3):241-9.

Mendzelevski, B., J. Ausma, D. O. Chanter, P. Robinson, R. Kerstens, L. Vandeplassche and J. Camm. Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo-and positive-controlled thorough QT study. Br J Clin Pharmacol. 2012 Feb;73(2):203-9. doi: 10.1111/j.1365-2125.2011.04088.x. PMID: 21848574 [PubMed - indexed for MEDLINE]

Mozley D, Bendtsen C, Zhao B, Schwartz L, Thorn M, Rong Y, Zhang L, Perrone A, Korn R, Buckler A. Measurement of Tumor Volumes Improves RECIST-Based Response Assessments in Advanced Lung Cancer. Translational Oncology (2012) 5, 19–25.

Schaerer, J., Fassi, A., Riboldi, M., Cerveri, P., Baroni, G., Sarrut, D. Multi-dimensional respiratory motion tracking from markerless optical surface imaging based on deformable mesh registration. Phys Med Biol. 2012 Jan 21;57(2):357-73. doi: 10.1088/0031-9155/57/2/357. Epub 2011 Dec 14. PMID: 22170786 [PubMed - indexed for MEDLINE]

Barbosa, D., Dietenbeck, T., Schaerer, J., D'Hooge, J., Friboulet, D., Bernard, O., 2012. B-spline explicit active surfaces: an efficient framework for real-time 3-D region-based segmentation. IEEE Trans Image Process. 2012 Jan;21(1):241-51. doi: 10.1109/TIP.2011.2161484. PMID: 22186712 [PubMed - indexed for MEDLINE]


Schuff N, Suhy J, Goldman R, Xu Y, Sun Y, Truran-Sacrey D, Murthy A. An MRI substudy of a donepezil clinical trial in mild cognitive impairment. Neurobiol Aging. 2011 Dec;32(12):2318.e31-41.

Yu HJ, Christodoulou C, Bhise V, Greenblatt D, Patel Y, Serafin D, Maletic-Savatic M, Krupp LB, Wagshul M. Multiple white matter tract abnormalities underlie cognitive impairment in RRMS. Neuroimage. 2011 Oct 29. PMID: 22062194

Metzler-Baddeley C, Jones DK, Belaroussi B, Aggleton JP, O'Sullivan MJ. Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study. J Neurosci. 2011 Sep 14;31(37):13236-45. PMID: 21917806

Duering M, Zieren N, Hervé D, Jouvent E, Reyes S, Peters N, Pachai C, Opherk C, Chabriat H, Dichgans M. Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL. Brain. 2011 Aug;134(Pt 8):2366-75. Epub 2011 Jul 14

Jack CR Jr, Barkhof F, Bernstein MA, Cantillon M, Cole PE, Decarli C, Dubois B, Duchesne S, Fox NC, Frisoni GB, Hampel H, Hill DL, Johnson K, Mangin JF, Scheltens P, Schwarz AJ, Sperling R, Suhy J, Thompson PM, Weiner M, Foster NL. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. Alzheimers Dement. 2011 Jul;7(4):474-485.

Carlson C, Estergard W, Oh J, Suhy J, Jack CR Jr, Siemers E, Barakos J. Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab. Alzheimers Dement. 2011 Jul;7(4):396-401.

Weiner MW, Sadowsky C, Saxton J, Hofbauer RK, Graham SM, Yu SY, Li S, Hsu HA, Suhy J, Fridman M, Perhach JL. Alzheimers Dement. Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease. 2011 Jul;7(4):425-35.

Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M. Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project. Journal of Neurology. 2011 May;258(5):795-803. PMID: 21128081

Aisen PS, Gauthier S, Ferris SH, Saumier D, Haine D, Garceau D, Duong A, Suhy J, Oh J, Lau WC, Sampalis J. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.

Bracoud L, Ahmad H, Brill-Almon E, Chertkoff R. Improving the accuracy of MRI spleen and liver volume measurements: A phase III Gaucher disease clinical trial setting as a model. Blood Cells Mol Dis. 2011 Jan 15;46(1):47-52. Epub 2010 Nov 17. PMID: 21084202


Tourdias T, Renou P, Sibon I, Asselineau J, Bracoud L, Dumoulin M, Rouanet F, Orgogozo JM, Dousset V. Final cerebral infarct volume is predictable by MR imaging at 1 week. AJNR Am J Neuroradiol. 2011 Feb;32(2):352-8. Epub 2010 Oct 21.

Parker J, Wolansky LJ, Khatry D, Geba GP, Molfino NA. Brain Magnetic Resonance Imaging in Adults with Asthma. Contemporary Clinical Trials.

Nonent M, Ben Salem D, Serfaty JM, Buthion V, Pasco-Papon A, Rotaru C, Bressollette L, Papon X, Pachai C, Fortrat JO, Gouny P, Badra A, Berge J, Le Bras Y, Cottier JP, Gauvrit JY, Douek P. Overestimation of moderate carotid stenosis assessed by both Doppler US and contrast enhanced 3D-MR angiography in the CARMEDAS study. J Neuroradiol. 2011 Jul;38(3):148-55. Epub 2010 Aug 21.


O'Sullivan M, Ngo E, Viswanathan A, Jouvent E, Gschwendtner A, Saemann PG, Duering M, Pachai C, Bousser MG, Chabriat H, Dichgans M. Hippocampal volume is an independent predictor of cognitive performance in CADASIL. Neurobiology of Aging. 2009 Jun;30(6):890-7. PMID: 17963999

Sibon I, Ménégon P, Orgogozo JM, Asselineau J, Rouanet F, Renou P, Tourdias T, Pachai C, Chêne G, Dousset V. Inter- and intraobserver reliability of five MRI sequences in the evaluation of the final volume of cerebral infarct. Journal of Magnetic Resonance Imaging. 2009 Jun;29(6):1280-4. PMID: 19472382

Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH; STAIR Group (contributor Ahmad H). Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations. Stroke. 2009 Jun;40(6):2244-50. doi: 10.1161/STROKEAHA.108.541128. Epub 2009 Feb 26. PMID: 19246690

Ford R, Schwartz L, Dancey J, Dodd LE, Eisenhauer EA, Gwyther S, Rubinstein L, Sargent D, Shankar L, Therasse P, Verweij J. Lessons Learned from Independent Central Review. European Journal of Cancer 45 (2009) 268–247.

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Danceya JE, Doddb LE, Ford R, Kapland R, Mooney M, Rubinstein L, Schwartze LH, Shankarb L, Therassef P. Recommendations for the Assessment of Progression in Randomised Cancer Treatment Trials. European Journal of Cancer 45 (2009) 281–289.

Hervé D, Godin O, Dufouil C, Viswanathan A, Jouvent E, Pachaï C, Guichard JP, Bousser MG, Dichgans M, Chabriat H. Three-dimensional MRI analysis of individual volume of Lacunes in CADASIL. Stroke. 2009 Jan;40(1):124-8. PMID: 18948610

Bogaerts J, Ford R, Sargent D, Schwartz LH, Rubinstein L, Lacombe D, Eisenhauer E, Verweij J, Therasse P, for the RECIST Working Party. Individual Patient Data Analysis to Assess Modifications to the RECIST Criteria. European Journal of Cancer 45 (2009) 248–260.


O'Sullivan M, Jouvent E, Saemann PG, Mangin JF, Viswanathan A, Gschwendtner A, Bracoud L, Pachai C, Chabriat H, Dichgans M. Measurement of brain atrophy in subcortical vascular disease: a comparison of different approaches and the impact of ischaemic lesions. Neuroimage. 2008 Nov 1;43(2):312-20. PMID: 18722537


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Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

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